PDB entry 2fvi

View 2fvi on RCSB PDB site
Description: Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP
Class: Transferase
Keywords: isoprenoid pathway, isopentenyl transferase, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on 2006-01-30, released 2006-03-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2007-06-19, with a file datestamp of 2007-06-15.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.212
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvia_
  • Chain 'B':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvib_
  • Chain 'C':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvic_
  • Chain 'D':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvid_
  • Chain 'E':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvie_
  • Chain 'F':
    Compound: Geranylgeranyl pyrophosphate synthetase
    Species: HOMO SAPIENS
    Gene: GGPS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O95749 (1-300)
      • cloning artifact (0)
    Domains in SCOPe 2.08: d2fvif_
  • Heterogens: MG, GRG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fviA (A:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviA (A:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fviB (B:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviB (B:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2fviC (C:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviC (C:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2fviD (D:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviD (D:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsnksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhy
ledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2fviE (E:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviE (E:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2fviF (F:)
smektqetvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhna
slliddiednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrql
lelhqgqgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllnt
lglffqirddyanlhskeysenksfcedltegkfsfptihaiwsrpestqvqnilrqrte
nidikkycvhyledvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmfkeen
e

    Sequence, based on observed residues (ATOM records): (download) 
    >2fviF (F:)
etvqrillepykyllqlpgkqvrtklsqafnhwlkvpedklqiiievtemlhnasllidd
iednsklrrgfpvahsiygipsvinsanyvyflglekvltldhpdavklftrqllelhqg
qgldiywrdnytcpteeeykamvlqktgglfglavglmqlfsdykedlkpllntlglffq
irddyanlhsksfcedltegkfsfptihaiwsrpestqvqnilrqrtenidikkycvhyl
edvgsfeytrntlkeleakaykqidarggnpelvalvkhlskmf