PDB entry 2fse
View 2fse on RCSB PDB site
Description: Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen
Class: immune system, structural protein
Keywords: rheumatoid arthritis, HLA-DR1, collagen type II, crystal structure, antigen presentation, IMMUNE SYSTEM, STRUCTURAL PROTEIN
Deposited on
2006-01-22, released
2006-09-19
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-02-24, with a file datestamp of
2009-02-03.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.222
AEROSPACI score: 0.2
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: H-2 class II histocompatibility antigen, E-K alpha chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2fsea1, d2fsea2 - Chain 'B':
Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2fseb1, d2fseb2 - Chain 'C':
Compound: H-2 class II histocompatibility antigen, E-K alpha chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2fsec1, d2fsec2 - Chain 'D':
Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2fsed1, d2fsed2 - Chain 'E':
Compound: Collagen alpha-1(II)
Species: Homo sapiens [TaxId:9606]
Gene: COL2A1
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: Collagen alpha-1(II)
Species: Homo sapiens [TaxId:9606]
Gene: COL2A1
Database cross-references and differences (RAF-indexed):
- Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>2fseA (A:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvapevtvlsrspvnlgepnilicfidkfsppvvnvtwlr
ngrpvtegvsetvflprddhlfrkfhyltflpstddfydcevdhwgleeplrkhwefe
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2fseB (B:)
rprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywns
qkdlleqrraavdtycrhnygvgesftvqrrveptvtvyptktqplqhhnllvcsvsdfy
pgnievrwfrngkeeetgivstglvrngdwtfqtlvmletvpqsgevytcqvehpsltdp
vtvewka
Sequence, based on observed residues (ATOM records): (download)
>2fseB (B:)
prflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywnsq
kdlleqrraavdtycrhnygvgesftvqrrveptvtvyptktqplqhhnllvcsvsdfyp
gnievrwfrngkeeetgivstglvrngdwtfqtlvmletvpqsgevytcqvehpsltdpv
tvewka
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2fseC (C:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvapevtvlsrspvnlgepnilicfidkfsppvvnvtwlr
ngrpvtegvsetvflprddhlfrkfhyltflpstddfydcevdhwgleeplrkhwefe
Sequence, based on observed residues (ATOM records): (download)
>2fseC (C:)
ehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalani
avdkanleimtkrsnytpitnvapevtvlsrspvnlgepnilicfidkfsppvvnvtwlr
ngrpvtegvsetvflprddhlfrkfhyltflpstddfydcevdhwgleeplrkhwef
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2fseD (D:)
rprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywns
qkdlleqrraavdtycrhnygvgesftvqrrveptvtvyptktqplqhhnllvcsvsdfy
pgnievrwfrngkeeetgivstglvrngdwtfqtlvmletvpqsgevytcqvehpsltdp
vtvewka
Sequence, based on observed residues (ATOM records): (download)
>2fseD (D:)
rprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywns
qkdlleqrraavdtycrhnygvgesftvqrrveptvtvyptktqplqhhnllvcsvsdfy
pgnievrwfrngkeeetgivstglvrngdwtfqtlvmletvpqsgevytcqvehpsltdp
vtvewk
- Chain 'E':
No sequence available.
- Chain 'F':
No sequence available.