PDB entry 2flr

View 2flr on RCSB PDB site
Description: Novel 5-Azaindole Factor VIIa Inhibitors
Class: hydrolase/blood clotting
Keywords: short hydrogen bond, 5-Azaindole inhibitors, S1 site
Deposited on 2006-01-06, released 2007-01-23
The last revision prior to the SCOP 1.73 freeze date was dated 2007-01-23, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.223
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2flrh1
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: HOMO SAPIENS
    Gene: F7
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: tissue factor
    Species: HOMO SAPIENS
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d2flrt1, d2flrt2
  • Heterogens: 7NH, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2flrH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    No sequence available.

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2flrT (T:)
    gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
    eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
    kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
    genycfsvqavipsrtvnrkstdspvecmgqekgefre
    

    Sequence, based on observed residues (ATOM records): (download)
    >2flrT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
    dvfgkdliytlyysvqavipsrtvnrkstds