PDB entry 2fb8

View 2fb8 on RCSB PDB site
Description: Structure of the B-Raf kinase domain bound to SB-590885
Class: transferase
Keywords: kinase domain, TRANSFERASE
Deposited on 2005-12-08, released 2006-12-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.203
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: B-Raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2fb8a_
  • Chain 'B':
    Compound: B-Raf proto-oncogene serine/threonine-protein kinase
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2fb8b_
  • Heterogens: 215, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2fb8A (A:)
gsdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknev
gvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaq
gmdylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmap
evirmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvr
sncpkamkrlmaeclkkkrderplfpqilasiellarslpk

    Sequence, based on observed residues (ATOM records): (download) 
    >2fb8A (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvsgsilwmapevirmqdknpysfqsdvya
fgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkr
derplfpqilasiellars

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2fb8B (B:)
gsdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknev
gvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaq
gmdylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmap
evirmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvr
sncpkamkrlmaeclkkkrderplfpqilasiellarslpk

    Sequence, based on observed residues (ATOM records): (download) 
    >2fb8B (B:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvsgsilwmapevirmqdknpysfqsdvya
fgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpkamkrlmaeclkkkr
derplfpqilasiellars