PDB entry 2f5b

View 2f5b on RCSB PDB site
Description: crystal structure of fab' from the hiv-1 neutralizing antibody 2f5 in complex with its gp41 epitope
Class: immunoglobulin
Keywords: fab complex, hiv-1 neutralization, gp41, immunoglobulin
Deposited on 1999-04-09, released 2003-07-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-12-29, with a file datestamp of 2009-12-24.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.232
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: protein (antibody 2f5 (heavy chain))
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2F5B (0-234)
    Domains in SCOPe 2.05: d2f5bh1, d2f5bh2
  • Chain 'L':
    Compound: protein (antibody 2f5 (light chain))
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2F5B (0-213)
    Domains in SCOPe 2.05: d2f5bl1, d2f5bl2
  • Chain 'P':
    Compound: protein (gp41 epitope)
    Database cross-references and differences (RAF-indexed):
    • PDB 2F5B (0-6)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >2f5bH (H:)
ritlkesgpplvkptqtltltcsfsgfslsdfgvgvgwirqppgkalewlaiiysdddkr
yspslntrltitkdtsknqvvlvmtrvspvdtatyfcahrrgpttlfgvpiargpvnamd
vwgqgitvtisststkgpsvfplapsskstaggaaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtytcnvnhkpsntkvdkrvepksc

    Sequence, based on observed residues (ATOM records): (download) 
    >2f5bH (H:)
ritlkesgpplvkptqtltltcsfsgfslsdfgvgvgwirqppgkalewlaiiysdddkr
yspslntrltitkdtsknqvvlvmtrvspvdtatyfcahrrgpttlfgvpiargpvnamd
vwgqgitvtisststkgpsvfplapssaggaaalgclvkdyfpepvtvswnsgaltsgvh
tfpavlqssglyslssvvtvpssslgtqtytcnvnhkpsntkvdkrvepksc

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2f5bL (L:)
alqltqspsslsasvgdrititcrasqgvtsalawyrqkpgsppqlliydasslesgvps
rfsgsgsgteftltistlrpedfatyycqqlhfyphtfgggtrvdvrrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyecevthqglsspvtksfnrgec

  • Chain 'P':
    No sequence available.