PDB entry 2f3h

View 2f3h on RCSB PDB site
Description: Mechanism of displacement of a catalytically essential loop from the active site of fructose-1,6-bisphosphatase
Class: hydrolase
Keywords: allosteric regulation, allostery, enzyme catalysis, loop displacement, FBPase, fructose-1,6-bisphosphatase, HYDROLASE
Deposited on 2005-11-21, released 2006-04-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-07-24, with a file datestamp of 2013-07-19.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.199
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Sus scrofa [TaxId:9823]
    Gene: FBP1,FBP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00636
      • engineered (10)
    Domains in SCOPe 2.08: d2f3ha_
  • Chain 'B':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Sus scrofa [TaxId:9823]
    Gene: FBP1,FBP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00636 (Start-337)
      • engineered (10)
    Domains in SCOPe 2.08: d2f3hb_
  • Heterogens: F6P, PO4, MG, AMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2f3hA (A:)
mtdqaafdtndvtltrfvmeegrkargtgemtqllnslctavkaistavrkagiahlygi
agstnvtgdqvkkldvlsndlvinvlkssfatcvlvseedknaiivepekrgkyvvcfdp
ldgssnidclvsigtifgiyrknstdepsekdalqpgrnlvaagyalygsatmlvlamvn
gvncfmldpaigefilvdrdvkikkkgsiysinegyakefdpaiteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggifmypankkspkgklrllyecnpmayvmekagglattgk
eavldivptdihqrapiilgspedvtelleiyqkhaak

    Sequence, based on observed residues (ATOM records): (download) 
    >2f3hA (A:)
tndvtltrfvmeegrkargtgemtqllnslctavkaistavrkagiahlygiagstnvtg
dqvkkldvlsndlvinvlkssfatcvlvseedknaiivepekrgkyvvcfdpldgssnid
clvsigtifgiyrknstdepsekdalqpgrnlvaagyalygsatmlvlamvngvncfmld
paigefilvdrdvkikkkgsiysinegyakefdpaiteyiqrkkfppdnsapygaryvgs
mvadvhrtlvyggifmypankkspkgklrllyecnpmayvmekagglattgkeavldivp
tdihqrapiilgspedvtelleiyqkha

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2f3hB (B:)
mtdqaafdtndvtltrfvmeegrkargtgemtqllnslctavkaistavrkagiahlygi
agstnvtgdqvkkldvlsndlvinvlkssfatcvlvseedknaiivepekrgkyvvcfdp
ldgssnidclvsigtifgiyrknstdepsekdalqpgrnlvaagyalygsatmlvlamvn
gvncfmldpaigefilvdrdvkikkkgsiysinegyakefdpaiteyiqrkkfppdnsap
ygaryvgsmvadvhrtlvyggifmypankkspkgklrllyecnpmayvmekagglattgk
eavldivptdihqrapiilgspedvtelleiyqkhaak

    Sequence, based on observed residues (ATOM records): (download) 
    >2f3hB (B:)
ndvtltrfvmeegrkargtgemtqllnslctavkaistavrkagiahlygiagstnvtgd
qvkkldvlsndlvinvlkssfatcvlvseedknaiivepekrgkyvvcfdpldgssnidc
lvsigtifgiyrknstdepsekdalqpgrnlvaagyalygsatmlvlamvngvncfmldp
aigefilvdrdvkikkkgsiysinegyakefdpaiteyiqrkkfppdnsapygaryvgsm
vadvhrtlvyggifmypankkspkgklrllyecnpmayvmekagglattgkeavldivpt
dihqrapiilgspedvtelleiyqkhaak