PDB entry 2f24

View 2f24 on RCSB PDB site
Description: Crystal Structure of the Human Sialidase Neu2 E111Q Mutant
Class: hydrolase
Keywords: SIALIDASE, NEURAMINIDASE, GANGLIOSIDE, DRUG DESIGN, hydrolase
Deposited on 2005-11-15, released 2006-11-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: 0.198
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sialidase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y3R4
      • engineered (112)
    Domains in SCOPe 2.07: d2f24a_
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2f24A (A:)
    gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgd
    ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtr
    anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
    yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
    hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
    thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
    yeeivflmftlkqafpaeylpq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2f24A (A:)
    slpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvqw
    qaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtranvtrlcqvt
    stdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiq
    rpipsafcflshdhgrtwarghfvaqdtlecqvaevqrvvtlnarshlrarvqaqstndg
    ldfqesqlvkklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppap
    eawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaey