PDB entry 2dvr

View 2dvr on RCSB PDB site
Description: Crystal structure analysis of the N-terminal bromodomain of human BRD2 complexed with acetylated histone H4 peptide
Class: transcription
Keywords: alpha-helical domain, bromodomain, binds to acetylated histones, Structural Genomics, NPPSFA, National Project on Protein Structural and Functional Analyses, RIKEN Structural Genomics/Proteomics Initiative, RSGI, TRANSCRIPTION
Deposited on 2006-08-01, released 2007-08-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2010-03-16, with a file datestamp of 2010-03-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.182
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440 (0-End)
      • modified residue (14)
      • modified residue (48)
      • modified residue (50)
      • modified residue (69)
      • modified residue (75)
      • modified residue (92)
      • modified residue (107)
    Domains in SCOPe 2.05: d2dvra_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440 (0-End)
      • modified residue (14)
      • modified residue (48)
      • modified residue (50)
      • modified residue (69)
      • modified residue (75)
      • modified residue (92)
      • modified residue (107)
    Domains in SCOPe 2.05: d2dvrb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P25440
      • modified residue (14)
      • modified residue (48)
      • modified residue (50)
      • modified residue (69)
      • modified residue (75)
      • modified residue (92)
      • modified residue (107)
    Domains in SCOPe 2.05: d2dvrc_
  • Chain 'P':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2DVR (Start-14)
  • Chain 'Q':
    Compound: histone h4
    Species: synthetic, synthetic
    Database cross-references and differences (RAF-indexed):
    • PDB 2DVR (Start-14)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2dvrA (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >2dvrA (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2dvrB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >2dvrB (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqee

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2dvrC (C:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >2dvrC (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.