PDB entry 2cmc

View 2cmc on RCSB PDB site
Description: Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Class: hydrolase
Keywords: polymorphism, phosphorylation, protein phosphatase, endoplasmic reticulum, oxidation, hydrolase, acetylation, phosphatase
Deposited on 2006-05-04, released 2006-08-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (7-End)
    • PDB 2CMC (1-6)
    Domains in SCOPe 2.08: d2cmca2, d2cmca3
  • Heterogens: DFM, SO4, BOG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2cmcA (A:)
mhhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdh
sriklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvm
ekgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhf
hyttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclll
mdkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkel
shed

    Sequence, based on observed residues (ATOM records): (download) 
    >2cmcA (A:)
hhhhhhemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
kgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfh
yttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllm
dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfi