PDB entry 2c6c

View 2c6c on RCSB PDB site
Description: membrane-bound glutamate carboxypeptidase II (gcpii) in complex with gpi-18431 (s)-2-(4-iodobenzylphosphonomethyl)-pentanedioic acid
Class: hydrolase
Keywords: naaladase, neurodegenerative disease, peptidase, prostate cancer, psma, glycoprotein, hydrolase, alternative splicing, antigen, carboxypeptidase, dipeptidase, metal-binding, metalloprotease, multifunctional enzyme, polymorphism, signal-anchor, transmembrane, zinc
Deposited on 2005-11-09, released 2006-02-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.191
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glutamate carboxypeptidase II
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2c6ca1, d2c6ca2, d2c6ca3
  • Heterogens: ZN, CA, CL, NAG, 24I, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2c6cA (A:)
    kssneatnitpkhnmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkef
    gldsvelahydvllsypnkthpnyisiinedgneifntslfeppppgyenvsdivppfsa
    fspqgmpegdlvyvnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlagak
    gvilysdpadyfapgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrrgi
    aeavglpsipvhpigyydaqkllekmggsappdsswrgslkvpynvgpgftgnfstqkvk
    mhihstnevtriynvigtlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfg
    tlkkegwrprrtilfaswdaeefgllgstewaeensrllqergvayinadssiegnytlr
    vdctplmyslvhnltkelkspdegfegkslyeswtkkspspefsgmprisklgsgndfev
    ffqrlgiasgrarytknwetnkfsgyplyhsvyetyelvekfydpmfkyhltvaqvrggm
    vfelansivlpfdcrdyavvlrkyadkiysismkhpqemktysvsfdslfsavknfteia
    skfserlqdfdksnpivlrmmndqlmflerafidplglpdrpfyrhviyapsshnkyage
    sfpgiydalfdieskvdpskawgevkrqiyvaaftvqaaaetlseva
    

    Sequence, based on observed residues (ATOM records): (download)
    >2c6cA (A:)
    nmkafldelkaenikkflynftqiphlagteqnfqlakqiqsqwkefgldsvelahydvl
    lsypnkthpnyisiinedgneifntslfeppppgyenvsdivppfsafspqgmpegdlvy
    vnyartedffklerdmkincsgkiviarygkvfrgnkvknaqlagakgvilysdpadyfa
    pgvksypdgwnlpgggvqrgnilnlngagdpltpgypaneyayrrgiaeavglpsipvhp
    igyydaqkllekmggsappdsswrgslkvpynvgpgfstqkvkmhihstnevtriynvig
    tlrgavepdryvilgghrdswvfggidpqsgaavvheivrsfgtlkkegwrprrtilfas
    wdaeefgllgstewaeensrllqergvayinadssiegnytlrvdctplmyslvhnltke
    lkspdegfegkslyeswtkkspspefsgmprisklgsgndfevffqrlgiasgrarytkn
    sgyplyhsvyetyelvekfydpmfkyhltvaqvrggmvfelansivlpfdcrdyavvlrk
    yadkiysismkhpqemktysvsfdslfsavknfteiaskfserlqdfdnpivlrmmndql
    mflerafidplglpdrpfyrhviyapsshnkyagesfpgiydalfdieskvdpskawgev
    krqiyvaaftvqaaaetlseva