PDB entry 2c4g

View 2c4g on RCSB PDB site
Description: structure of cdk2-cyclin a with pha-533514
Class: transferase
Keywords: protein kinase, transferase, serine/threonine-protein kinase, phosphorylation, cell division, cyclin, ATP-binding, cell cycle, mitosis, nucleotide-binding, phosphorylation, polymorphism
Deposited on 2005-10-19, released 2005-11-23
The last revision prior to the SCOP 1.75 freeze date was dated 2006-01-11, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.233
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c4ga1
  • Chain 'B':
    Compound: cyclin a2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c4gb1, d2c4gb2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c4gc1
  • Chain 'D':
    Compound: cyclin a2
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2c4gd1, d2c4gd2
  • Heterogens: SO4, 514, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2c4gA (A:)
gplvdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisll
kelnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgl
afchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeill
gckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpd
ykpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph
lrlerphrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2c4gA (A:)
plvdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllk
elnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgla
fchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillg
ckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdy
kpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphl
r

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2c4gB (B:)
gplgsnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeykl
qnetlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtyt
kkqvlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpy
lkylpsviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqq
sirekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c4gB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2c4gC (C:)
gplvdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisll
kelnhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqgl
afchshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeill
gckyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpd
ykpsfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvph
lrlerphrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2c4gC (C:)
vdmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2c4gD (D:)
gplgsnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeykl
qnetlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtyt
kkqvlrmehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpy
lkylpsviagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqq
sirekyknskyhgvsllnppetlnl

    Sequence, based on observed residues (ATOM records): (download) 
    >2c4gD (D:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl