PDB entry 2bw7

View 2bw7 on RCSB PDB site
Description: a novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen
Class: lyase
Keywords: lyase, adenylyl cyclase, camp signaling, catechol estrogen, inhibitor complex, oxidoreductase
Deposited on 2005-07-12, released 2005-07-20
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.207
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: adenylate cyclase
    Species: SPIRULINA PLATENSIS [TaxId:118562]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BW7 (Start-20)
    • Uniprot O32393 (21-215)
    Domains in SCOPe 2.05: d2bw7a_
  • Chain 'B':
    Compound: adenylate cyclase
    Species: SPIRULINA PLATENSIS [TaxId:118562]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BW7 (Start-20)
    • Uniprot O32393 (21-215)
    Domains in SCOPe 2.05: d2bw7b_
  • Chain 'C':
    Compound: adenylate cyclase
    Species: SPIRULINA PLATENSIS [TaxId:118562]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BW7 (Start-20)
    • Uniprot O32393 (21-215)
    Domains in SCOPe 2.05: d2bw7c_
  • Chain 'D':
    Compound: adenylate cyclase
    Species: SPIRULINA PLATENSIS [TaxId:118562]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BW7
    • Uniprot O32393 (21-215)
    Domains in SCOPe 2.05: d2bw7d_
  • Heterogens: APC, MG, CA, ECS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2bw7A (A:)
    mgsshhhhhhssglvprgshmrpeprlitilfsdivgftrmsnalqsqgvaellneylge
    mtravfenqgtvdkfvgdaimalygapeemspseqvrraiatarqmlvaleklnqgwqer
    glvgrnevppvrfrcgihqgmavvglfgsqersdftaigpsvniaarlqeatapnsimvs
    amvaqyvpdeeiikreflelkgidepvmtcvinpnmlnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bw7A (A:)
    shmrpeprlitilfsdivgftrmsnalqsqgvaellneylgemtravfenqgtvdkfvgd
    aimalygapeemspseqvrraiatarqmlvaleklnqgwqerglvgrnevppvrfrcgih
    qgmavvglfgsqersdftaigpsvniaarlqeatapnsimvsamvaqyvpdeeiikrefl
    elkgidepvmtcvinpnm
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2bw7B (B:)
    mgsshhhhhhssglvprgshmrpeprlitilfsdivgftrmsnalqsqgvaellneylge
    mtravfenqgtvdkfvgdaimalygapeemspseqvrraiatarqmlvaleklnqgwqer
    glvgrnevppvrfrcgihqgmavvglfgsqersdftaigpsvniaarlqeatapnsimvs
    amvaqyvpdeeiikreflelkgidepvmtcvinpnmlnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bw7B (B:)
    mrpeprlitilfsdivgftrmsnalqsqgvaellneylgemtravfenqgtvdkfvgdai
    malygapeemspseqvrraiatarqmlvaleklnqgwqerglvgrppvrfrcgihqgmav
    vglfgsqersdftaigpsvniaarlqeatapnsimvsamvaqyvpdeeiikreflelkgi
    depvmtcvinpnm
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2bw7C (C:)
    mgsshhhhhhssglvprgshmrpeprlitilfsdivgftrmsnalqsqgvaellneylge
    mtravfenqgtvdkfvgdaimalygapeemspseqvrraiatarqmlvaleklnqgwqer
    glvgrnevppvrfrcgihqgmavvglfgsqersdftaigpsvniaarlqeatapnsimvs
    amvaqyvpdeeiikreflelkgidepvmtcvinpnmlnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bw7C (C:)
    mrpeprlitilfsdivgftrmsnalqsqgvaellneylgemtravfenqgtvdkfvgdai
    malygapeemspseqvrraiatarqmlvaleklnqgwqerglvgrnevppvrfrcgihqg
    mavvglfgsqersdftaigpsvniaarlqeatapnsimvsamvaqyvpdeeiikreflel
    kgidepvmtcvinpnm
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2bw7D (D:)
    mgsshhhhhhssglvprgshmrpeprlitilfsdivgftrmsnalqsqgvaellneylge
    mtravfenqgtvdkfvgdaimalygapeemspseqvrraiatarqmlvaleklnqgwqer
    glvgrnevppvrfrcgihqgmavvglfgsqersdftaigpsvniaarlqeatapnsimvs
    amvaqyvpdeeiikreflelkgidepvmtcvinpnmlnq
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bw7D (D:)
    rpeprlitilfsdivgftrmsnalqsqgvaellneylgemtravfenqgtvdkfvgdaim
    alygapeemspseqvrraiatarqmlvaleklnqgwqerglvgevppvrfrcgihqgmav
    vglfgsqersdftaigpsvniaarlqeatapnsimvsamvaqyvpdeeiikreflelkgi
    depvmtcvinpnm