PDB entry 2bvc

View 2bvc on RCSB PDB site
Description: crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic
Class: ligase
Keywords: ligase, transition state mimic, synthetase
Deposited on 2005-06-23, released 2005-07-07
The last revision prior to the SCOPe 2.02 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.193
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvca1, d2bvca2
  • Chain 'B':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvcb1, d2bvcb2
  • Chain 'C':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvcc1, d2bvcc2
  • Chain 'D':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvcd1, d2bvcd2
  • Chain 'E':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvce1, d2bvce2
  • Chain 'F':
    Compound: glutamine synthetase 1
    Species: Mycobacterium tuberculosis [TaxId:83332]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BVC
    • Uniprot P0A590 (Start-485)
    Domains in SCOPe 2.02: d2bvcf1, d2bvcf2
  • Heterogens: P3S, ADP, MG, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2bvcA (A:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcA (A:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2bvcB (B:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcB (B:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2bvcC (C:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcC (C:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2bvcD (D:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcD (D:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2bvcE (E:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcE (E:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2bvcF (F:)
mahhhhhhgtektpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddgla
fdgssirgfqsihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprnia
rkaenylistgiadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadg
spnrgykvrhkggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqf
nsllhaaddmqlykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmyde
tgyaglsdtarhyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvr
ipitgsnpkakrlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppee
aasipqtptqlsdvidrleadheylteggvftndlietwisfkreneiepvnirphpyef
alyydv

    Sequence, based on observed residues (ATOM records): (download) 
    >2bvcF (F:)
ktpddvfklakdekveyvdvrfcdlpgimqhftipasafdksvfddglafdgssirgfqs
ihesdmlllpdpetaridpfraaktlninffvhdpftlepysrdprniarkaenylistg
iadtayfgaeaefyifdsvsfdsrangsfyevdaisgwwntgaateadgspnrgykvrhk
ggyfpvapndqyvdlrdkmltnlinsgfilekghhevgsggqaeinyqfnsllhaaddmq
lykyiikntawqngktvtfmpkplfgdngsgmhchqslwkdgaplmydetgyaglsdtar
hyiggllhhapsllaftnptvnsykrlvpgyeapinlvysqrnrsacvripitgsnpkak
rlefrspdssgnpylafsamlmagldgiknkiepqapvdkdlyelppeeaasipqtptql
sdvidrleadheylteggvftndlietwisfkreneiepvnirphpyefalyydv