PDB entry 2bex

View 2bex on RCSB PDB site
Description: crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution
Class: hydrolase/inhibitor
Keywords: hydrolase/inhibitor, complex (inhibitor/nuclease), ribonuclease inhibitor, eosinophil derived neurotoxin, RNAse 2, luecine-rich repeats, protein-protein interaction, molecular recognition, x-ray crystallography
Deposited on 2004-12-01, released 2005-03-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: 0.2059
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ribonuclease inhibitor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bexa_
  • Chain 'B':
    Compound: ribonuclease inhibitor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d2bexb_
  • Chain 'C':
    Compound: nonsecretory ribonuclease
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BEX (0-0)
    • Uniprot P10153 (1-134)
    Domains in SCOPe 2.07: d2bexc2, d2bexc3
  • Chain 'D':
    Compound: nonsecretory ribonuclease
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2BEX (0-0)
    • Uniprot P10153 (1-134)
    Domains in SCOPe 2.07: d2bexd2, d2bexd3
  • Heterogens: GOL, MAK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2bexA (A:)
    sldiqsldiqceelsdarwaellpllqqcqvvrlddcgltearckdissalrvnpalael
    nlrsnelgdvgvhcvlqglqtpsckiqklslqnccltgagcgvlsstlrtlptlqelhls
    dnllgdaglqllceglldpqcrleklqleycslsaasceplasvlrakpdfkeltvsnnd
    ineagvrvlcqglkdspcqlealklescgvtsdncrdlcgivaskaslrelalgsnklgd
    vgmaelcpgllhpssrlrtlwiwecgitakgcgdlcrvlrakeslkelslagnelgdega
    rllcetllepgcqleslwvkscsftaaccshfssvlaqnrfllelqisnnrledagvrel
    cqglgqpgsvlrvlwladcdvsdsscsslaatllanhslreldlsnnclgdagilqlves
    vrqpgclleqlvlydiywseemedrlqalekdkpslrvis
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bexA (A:)
    qsldiqceelsdarwaellpllqqcqvvrlddcgltearckdissalrvnpalaelnlrs
    nelgdvgvhcvlqglqtpsckiqklslqnccltgagcgvlsstlrtlptlqelhlsdnll
    gdaglqllceglldpqcrleklqleycslsaasceplasvlrakpdfkeltvsnndinea
    gvrvlcqglkdspcqlealklescgvtsdncrdlcgivaskaslrelalgsnklgdvgma
    elcpgllhpssrlrtlwiwecgitakgcgdlcrvlrakeslkelslagnelgdegarllc
    etllepgcqleslwvkscsftaaccshfssvlaqnrfllelqisnnrledagvrelcqgl
    gqpgsvlrvlwladcdvsdsscsslaatllanhslreldlsnnclgdagilqlvesvrqp
    gclleqlvlydiywseemedrlqalekdkpslrvis
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2bexB (B:)
    sldiqsldiqceelsdarwaellpllqqcqvvrlddcgltearckdissalrvnpalael
    nlrsnelgdvgvhcvlqglqtpsckiqklslqnccltgagcgvlsstlrtlptlqelhls
    dnllgdaglqllceglldpqcrleklqleycslsaasceplasvlrakpdfkeltvsnnd
    ineagvrvlcqglkdspcqlealklescgvtsdncrdlcgivaskaslrelalgsnklgd
    vgmaelcpgllhpssrlrtlwiwecgitakgcgdlcrvlrakeslkelslagnelgdega
    rllcetllepgcqleslwvkscsftaaccshfssvlaqnrfllelqisnnrledagvrel
    cqglgqpgsvlrvlwladcdvsdsscsslaatllanhslreldlsnnclgdagilqlves
    vrqpgclleqlvlydiywseemedrlqalekdkpslrvis
    

    Sequence, based on observed residues (ATOM records): (download)
    >2bexB (B:)
    iqsldiqceelsdarwaellpllqqcqvvrlddcgltearckdissalrvnpalaelnlr
    snelgdvgvhcvlqglqtpsckiqklslqnccltgagcgvlsstlrtlptlqelhlsdnl
    lgdaglqllceglldpqcrleklqleycslsaasceplasvlrakpdfkeltvsnndine
    agvrvlcqglkdspcqlealklescgvtsdncrdlcgivaskaslrelalgsnklgdvgm
    aelcpgllhpssrlrtlwiwecgitakgcgdlcrvlrakeslkelslagnelgdegarll
    cetllepgcqleslwvkscsftaaccshfssvlaqnrfllelqisnnrledagvrelcqg
    lgqpgsvlrvlwladcdvsdsscsslaatllanhslreldlsnnclgdagilqlvesvrq
    pgclleqlvlydiywseemedrlqalekdkpslrvis
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2bexC (C:)
    mkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntfllttfanvvnvcgnpn
    mtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdnrdqrrd
    ppqypvvpvhldrii
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2bexD (D:)
    mkppqftwaqwfetqhinmtsqqctnamqvinnyqrrcknqntfllttfanvvnvcgnpn
    mtcpsnktrknchhsgsqvplihcnlttpspqnisncryaqtpanmfyivacdnrdqrrd
    ppqypvvpvhldrii