PDB entry 2b7d

View 2b7d on RCSB PDB site
Description: Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
Class: blood clotting
Keywords: short hydrogen bond, BLOOD CLOTTING
Deposited on 2005-10-04, released 2006-02-14
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: 0.247
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2b7dh_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2b7dl1, d2b7dl2
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2b7dt1, d2b7dt2
  • Heterogens: C1B, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2b7dH (H:)
    ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
    lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
    lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
    sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
    seprpgvllrapfp
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2b7dL (L:)
    anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
    ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
    ladgvsctptveypcgkipilekrnaskpqgr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b7dL (L:)
    qcasspcqnggsckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgt
    krscrchegyslladgvsctptveypcgkipile
    

  • Chain 'T':
    Sequence, based on SEQRES records: (download)
    >2b7dT (T:)
    gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
    eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
    kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
    genycfsvqavipsrtvnrkstdspvecmgqekgefre
    

    Sequence, based on observed residues (ATOM records): (download)
    >2b7dT (T:)
    tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
    dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
    dvfgkdliytlsvqavipsrtvnrkstds