PDB entry 2b7d
View 2b7d on RCSB PDB site
Description: Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model
Class: blood clotting
Keywords: short hydrogen bond
Deposited on
2005-10-04, released
2006-02-14
The last revision prior to the SCOP 1.73 freeze date was dated
2006-03-21, with a file datestamp of
2007-06-28.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: 0.247
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: Coagulation factor VII
Species: HOMO SAPIENS
Gene: F7
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2b7dh1 - Chain 'L':
Compound: Coagulation factor VII
Species: HOMO SAPIENS
Gene: F7
Database cross-references and differences (RAF-indexed):
- Chain 'T':
Compound: tissue factor
Species: HOMO SAPIENS
Gene: F3
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d2b7dt1, d2b7dt2 - Heterogens: C1B, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>2b7dH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp
- Chain 'L':
No sequence available.
- Chain 'T':
Sequence, based on SEQRES records: (download)
>2b7dT (T:)
gttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltd
eivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvgt
kvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdk
genycfsvqavipsrtvnrkstdspvecmgqekgefre
Sequence, based on observed residues (ATOM records): (download)
>2b7dT (T:)
tvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdeivk
dvkqtylarvfsypagnvestgsageplyenspeftpyletnlgdertlvrrnntflslr
dvfgkdliytlsvqavipsrtvnrkstds