PDB entry 2b5t

View 2b5t on RCSB PDB site
Description: 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
Class: Blood Clotting
Keywords: Blood coagulation
Deposited on 2005-09-29, released 2006-09-19
The last revision prior to the SCOP 1.75 freeze date was dated 2006-09-19, with a file datestamp of 2007-07-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.209
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thrombin
    Species: HOMO SAPIENS
    Gene: F2
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: thrombin
    Species: HOMO SAPIENS
    Gene: F2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-258)
      • engineered (204)
  • Chain 'C':
    Compound: thrombin
    Species: HOMO SAPIENS
    Gene: F2
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: thrombin
    Species: HOMO SAPIENS
    Gene: F2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00734 (0-258)
      • engineered (204)
  • Chain 'I':
    Compound: antithrombin-III
    Species: HOMO SAPIENS
    Gene: SERPINC1, AT3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01008
      • engineered (136)
      • engineered (316)
      • engineered (400)
    Domains in SCOP 1.75: d2b5ti1
  • Heterogens: NAG, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >2b5tI (I:)
hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
fffaklncrlyrkankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
pevlqewldeleemmlcvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
dlyvsdafhkaflevneegseaaastavviagrslnpnrvcfkanrpflvfirevplnti
ifmgrvanpcvk

    Sequence, based on observed residues (ATOM records): (download) 
    >2b5tI (I:)
dictakprdipmnpmciyrspekipeatnrrvwelskansrfattfyqhladskndndni
flsplsistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkank
asklvsanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnkteg
ritdvipseaineltvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqeg
kfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemml
cvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrddlyvsdafhkaflevn
eegseaaastavviagrslnpnrvcfkanrpflvfirevplntiifmgrvanpcv