PDB entry 2b2x

View 2b2x on RCSB PDB site
Description: VLA1 RdeltaH I-domain complexed with a quadruple mutant of the AQC2 Fab
Class: Immune system
Keywords: computational design, antibody-antigen complex
Deposited on 2005-09-19, released 2006-04-18
The last revision prior to the SCOP 1.75 freeze date was dated 2006-05-09, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.241
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrin alpha-1
    Species: Rattus norvegicus
    Gene: Itga1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614
      • engineered (92-94)
      • engineered (97)
    Domains in SCOP 1.75: d2b2xa1
  • Chain 'B':
    Compound: integrin alpha-1
    Species: Rattus norvegicus
    Gene: Itga1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18614
      • engineered (92-94)
      • engineered (97)
    Domains in SCOP 1.75: d2b2xb1
  • Chain 'H':
    Compound: Antibody AQC2 Fab
    Species: MUS MUSCULUS
  • Chain 'I':
    Compound: Antibody AQC2 Fab
    Species: MUS MUSCULUS
  • Chain 'L':
    Compound: Antibody AQC2 Fab
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d2b2xl1, d2b2xl2
  • Chain 'M':
    Compound: Antibody AQC2 Fab
    Species: MUS MUSCULUS
    Domains in SCOP 1.75: d2b2xm1, d2b2xm2
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2b2xA (A:)
gsvsptfqvvnsfapvqecstqldivivldgsnsiypwesviaflndllkrmdigpkqtq
vgivqygenvthefnlnkyssteevlvaankivqrggrqtmtalgidtarkeaftearga
rrgvkkvmvivtdgeshdnyrlkqviqdcedeniqrfsiailghynrgnlstekfveeik
siaseptekhffnvsdelalvtivkalgerifalealerphrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2b2xA (A:)
qldivivldgsnsiypwesviaflndllkrmdigpkqtqvgivqygenvthefnlnkyss
teevlvaankivqrggrqtmtalgidtarkeafteargarrgvkkvmvivtdgeshdnyr
lkqviqdcedeniqrfsiailghynlstekfveeiksiaseptekhffnvsdelalvtiv
kalgerif

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2b2xB (B:)
gsvsptfqvvnsfapvqecstqldivivldgsnsiypwesviaflndllkrmdigpkqtq
vgivqygenvthefnlnkyssteevlvaankivqrggrqtmtalgidtarkeaftearga
rrgvkkvmvivtdgeshdnyrlkqviqdcedeniqrfsiailghynrgnlstekfveeik
siaseptekhffnvsdelalvtivkalgerifalealerphrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2b2xB (B:)
ldivivldgsnsiypwesviaflndllkrgpkqtqvgivqygenvthefnlnkyseevlv
aankivqrggrqtmtalgidtarkeafteargarkvmvivtdgeshdnyrlkqviqdced
eniqrfsiailghystekfveeiksiaseptekhffnvsdelalvtivkalgerif

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >2b2xL (L:)
qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >2b2xL (L:)
qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnr

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >2b2xM (M:)
qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >2b2xM (M:)
qiqltqspsslsasvgdrvtitcsassqvnhmfwyqqkpgkapkpwiyltsylasgvpsr
fsgsgsgtdytltisslqpedfatyycqqwsgnpwtfgqgtkveikradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnr