PDB entry 2aot

View 2aot on RCSB PDB site
Description: Histamine Methyltransferase Complexed with the Antihistamine Drug Diphenhydramine
Class: transferase
Keywords: classic methyltransferase fold, protein-drug complex
Deposited on 2005-08-14, released 2005-09-13
The last revision prior to the SCOP 1.75 freeze date was dated 2005-10-18, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.221
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: HNMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot P50135 (Start-291)
      • modified residue (81)
      • modified residue (216)
      • modified residue (247)
    Domains in SCOP 1.75: d2aota1
  • Chain 'B':
    Compound: Histamine N-methyltransferase
    Species: HOMO SAPIENS
    Gene: HNMT
    Domains in SCOP 1.75: d2aotb1
  • Heterogens: 2PM, SAH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aotA (A:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aotA (A:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aotB (B:)
massmrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsig
ggageidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhkets
seyqsrmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwd
klwkkygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdll
wdfltetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

    Sequence, based on observed residues (ATOM records): (download) 
    >2aotB (B:)
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea