PDB entry 2anw

View 2anw on RCSB PDB site
Description: Expression, crystallization and three-dimensional structure of the catalytic domain of human plasma kallikrein: Implications for structure-based design of protease inhibitors
Class: blood clotting, hydrolase
Keywords: trypsin-like serine protease; enzymatically deglycosylated, BLOOD CLOTTING, HYDROLASE
Deposited on 2005-08-11, released 2005-10-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: plasma kallikrein, light chain
    Species: Homo sapiens [TaxId:9606]
    Gene: KLKB1, KLK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03952 (0-End)
      • engineered (112)
    Domains in SCOPe 2.07: d2anwa_
  • Heterogens: BAM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2anwA (A:)
ivggtnsswgewpwqvslqvkltaqrhlcggslighqwvltaahcfdglplqdvwriysg
ilnlsditkdtpfsqikeiiihqnykvsegnhdialiklqaplnytefqkpislpskgdt
stiytncwvtgwgfskekgeiqnilqkvniplvtneecqkryqdykitqrmvcagykegg
kdackgdsggplvckhngmwrlvgitswgegcarreqpgvytkvaeymdwilektqssdg
k

    Sequence, based on observed residues (ATOM records): (download) 
    >2anwA (A:)
ivggtnsswgewpwqvslqvkltaqrhlcggslighqwvltaahcfdglplqdvwriysg
ilnlsditkdtpfsqikeiiihqnykvsegnhdialiklqaplnytefqkpislpskgdt
stiytncwvtgwgfskekgeiqnilqkvniplvtneecqkryqdykitqrmvcagykegg
kdackgdsggplvckhngmwrlvgitswgegcarreqpgvytkvaeymdwilektqss