PDB entry 2abj

View 2abj on RCSB PDB site
Description: Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
Class: transferase
Keywords: branched-chain-amino-acid aminotransferase, cytosolic, pyridoxal-phosphate-dependent aminotransferase, PLP-Lys220 Schiff base, inhibitor-bound, TRANSFERASE
Deposited on 2005-07-15, released 2006-06-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-11, with a file datestamp of 2017-10-06.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Branched-chain-amino-acid aminotransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT1, BCT1, ECA39
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54687 (0-365)
      • variant (144)
      • variant (216)
      • variant (230)
      • variant (296)
      • variant (309)
    Domains in SCOPe 2.08: d2abja_
  • Chain 'D':
    Compound: Branched-chain-amino-acid aminotransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT1, BCT1, ECA39
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54687 (0-End)
      • variant (144)
      • variant (216)
      • variant (230)
      • variant (296)
      • variant (309)
    Domains in SCOPe 2.08: d2abjd_
  • Chain 'G':
    Compound: Branched-chain-amino-acid aminotransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT1, BCT1, ECA39
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54687 (Start-365)
      • variant (144)
      • variant (216)
      • variant (230)
      • variant (296)
      • variant (309)
    Domains in SCOPe 2.08: d2abjg_
  • Chain 'J':
    Compound: Branched-chain-amino-acid aminotransferase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: BCAT1, BCT1, ECA39
    Database cross-references and differences (RAF-indexed):
    • Uniprot P54687 (0-365)
      • variant (144)
      • variant (216)
      • variant (230)
      • variant (296)
      • variant (309)
    Domains in SCOPe 2.08: d2abjj_
  • Heterogens: CBC, PLP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2abjA (A:)
vvgtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnls
lhpgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeellec
iqqlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpyfssgtfn
pvslwanpkyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgt
mnlflywinedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttal
egnrvremfssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesd
wtivls

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2abjD (D:)
vvgtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnls
lhpgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeellec
iqqlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpyfssgtfn
pvslwanpkyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgt
mnlflywinedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttal
egnrvremfssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesd
wtivls

    Sequence, based on observed residues (ATOM records): (download) 
    >2abjD (D:)
vvgtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnls
lhpgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeellec
iqqlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpfnpvslwa
npkyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgtmnlfly
winedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttalegnrvr
emfssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesdwtivl

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >2abjG (G:)
vvgtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnls
lhpgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeellec
iqqlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpyfssgtfn
pvslwanpkyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgt
mnlflywinedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttal
egnrvremfssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesd
wtivls

    Sequence, based on observed residues (ATOM records): (download) 
    >2abjG (G:)
gtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnlslh
pgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeelleciq
qlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpfnpvslwanp
kyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgtmnlflywi
nedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttalegnrvrem
fssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesdwtivls

  • Chain 'J':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2abjJ (J:)
vvgtfkakdlivtpatilkekpdpnnlvfgtvftdhmltvewssefgwekphikplqnls
lhpgssalhyavelfeglkafrgvdnkirlfqpnlnmdrmyrsavratlpvfdkeellec
iqqlvkldqewvpystsaslyirpafigtepslgvkkptkallfvllspvgpyfssgtfn
pvslwanpkyvrawkggtgdckmggnygsslfaqcedvdngcqqvlwlygrdhqitevgt
mnlflywinedgeeelatppldgiilpgvtrrcildlahqwgefkvseryltmddlttal
egnrvremfssgtacvvcpvsdilykgetihiptmengpklasrilskltdiqygreesd
wtivls