PDB entry 2aax

View 2aax on RCSB PDB site
Description: Mineralocorticoid Receptor Double Mutant with Bound Cortisone
Class: transcription
Keywords: Mineralocorticoid receptor, MR, Nuclear Receptor, Steroid Receptor, Cortisone, Hypertension, TRANSCRIPTION
Deposited on 2005-07-14, released 2005-07-26
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.185
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.03: d2aaxa_
  • Chain 'B':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.03: d2aaxb_
  • Heterogens: SO4, PDN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2aaxA (A:)
    gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
    nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
    apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
    aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
    halkvefpamlveiisdqlpkvesgnakplyfhrk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aaxA (A:)
    alvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvv
    kwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmh
    qsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyik
    elrkmvtkcnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlve
    iisdqlpkvesgnakplyfhr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2aaxB (B:)
    gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
    nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
    apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
    aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
    halkvefpamlveiisdqlpkvesgnakplyfhrk
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aaxB (B:)
    lvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvk
    wakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmhq
    samyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyike
    lrkmvtnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiis
    dqlpkvesgnakplyfh