PDB entry 2aa6

View 2aa6 on RCSB PDB site
Description: Mineralocorticoid Receptor S810L Mutant with Bound Progesterone
Class: transcription
Keywords: Mineralocorticoid receptor, MR, Nuclear Receptor, Steroid Receptor, Progesterone, Hypertension, TRANSCRIPTION
Deposited on 2005-07-13, released 2005-07-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.197
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.06: d2aa6a_
  • Chain 'B':
    Compound: Mineralocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: NR3C2, MCR, MLR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08235
      • engineered (98)
      • engineered (100)
    Domains in SCOPe 2.06: d2aa6b_
  • Heterogens: STR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2aa6A (A:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >2aa6A (A:)
alvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvv
kwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmh
qsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyik
elrkmvtkcnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlve
iisdqlpkvesgnakplyfh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2aa6B (B:)
gsapakepsvntalvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstl
nrlagkqmiqvvkwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyf
apdlvfneekmhqsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksq
aafeemrtnyikelrkmvtkcpnnsgqswqrfyqltklldsmhdlvsdllefcfytfres
halkvefpamlveiisdqlpkvesgnakplyfhrk

    Sequence, based on observed residues (ATOM records): (download) 
    >2aa6B (B:)
alvpqlstisraltpspvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvv
kwakvlpgfknlpledqitliqyswmsllsfalswrsykhtnsqflyfapdlvfneekmh
qsamyelcqgmhqislqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyik
elrkmvtpnnsgqswqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlvei
isdqlpkvesgnakplyfh