PDB entry 2a1t

View 2a1t on RCSB PDB site
Description: Structure of the human MCAD:ETF E165betaA complex
Class: oxidoreductase/electron transport
Keywords: electron transfer, domain dynamics, conformational sampling, protein:protein complex, fatty acid b-degradation, OXIDOREDUCTASE/ELECTRON TRANSPORT COMPLEX
Deposited on 2005-06-21, released 2005-07-05
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.203
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1ta1, d2a1ta2
  • Chain 'B':
    Compound: Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1tb1, d2a1tb2
  • Chain 'C':
    Compound: Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1tc1, d2a1tc2
  • Chain 'D':
    Compound: Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1td1, d2a1td2
  • Chain 'R':
    Compound: Electron transfer flavoprotein alpha-subunit, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2a1tr1, d2a1tr2
  • Chain 'S':
    Compound: Electron transfer flavoprotein beta-subunit
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P38117
      • engineered (164)
    Domains in SCOPe 2.05: d2a1ts1
  • Heterogens: AMP, FAD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2a1tA (A:)
maagfgrccrvlrsisrfhwrsqhtkanrqrepglgfsfefteqqkefqatarkfareei
ipvaaeydktgeypvplirrawelglmnthipencgglglgtfdacliseelaygctgvq
taiegnslgqmpiiiagndqqkkkylgrmteeplmcaycvtepgagsdvagiktkaekkg
deyiingqkmwitnggkanwyfllarsdpdpkapankaftgfiveadtpgiqigrkelnm
gqrcsdtrgivfedvkvpkenvligdgagfkvamgafdktrpvvaagavglaqraldeat
kyalerktfgkllvehqaisfmlaemamkvelarmsyqraawevdsgrrntyyasiakaf
agdianqlatdavqilggngfnteypveklmrdakiyqiyegtsqiqrlivarehidkyk
n

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tA (A:)
lgfsfefteqqkefqatarkfareeiipvaaeydktgeypvplirrawelglmnthipen
cgglglgtfdacliseelaygctgvqtaiegnslgqmpiiiagndqqkkkylgrmteepl
mcaycvtepgagsdvagiktkaekkgdeyiingqkmwitnggkanwyfllarsdpdpkap
ankaftgfiveadtpgiqigrkelnmgqrcsdtrgivfedvkvpkenvligdgagfkvam
gafdktrpvvaagavglaqraldeatkyalerktfgkllvehqaisfmlaemamkvelar
msyqraawevdsgrrntyyasiakafagdianqlatdavqilggngfnteypveklmrda
kiyqiyegtsqiqrlivarehidkyk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2a1tB (B:)
maagfgrccrvlrsisrfhwrsqhtkanrqrepglgfsfefteqqkefqatarkfareei
ipvaaeydktgeypvplirrawelglmnthipencgglglgtfdacliseelaygctgvq
taiegnslgqmpiiiagndqqkkkylgrmteeplmcaycvtepgagsdvagiktkaekkg
deyiingqkmwitnggkanwyfllarsdpdpkapankaftgfiveadtpgiqigrkelnm
gqrcsdtrgivfedvkvpkenvligdgagfkvamgafdktrpvvaagavglaqraldeat
kyalerktfgkllvehqaisfmlaemamkvelarmsyqraawevdsgrrntyyasiakaf
agdianqlatdavqilggngfnteypveklmrdakiyqiyegtsqiqrlivarehidkyk
n

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tB (B:)
lgfsfefteqqkefqatarkfareeiipvaaeydktgeypvplirrawelglmnthipen
cgglglgtfdacliseelaygctgvqtaiegnslgqmpiiiagndqqkkkylgrmteepl
mcaycvtepgagsdvagiktkaekkgdeyiingqkmwitnggkanwyfllarsdpdpkap
ankaftgfiveadtpgiqigrkelnmgqrcsdtrgivfedvkvpkenvligdgagfkvam
gafdktrpvvaagavglaqraldeatkyalerktfgkllvehqaisfmlaemamkvelar
msyqraawevdsgrrntyyasiakafagdianqlatdavqilggngfnteypveklmrda
kiyqiyegtsqiqrlivarehidkykn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2a1tC (C:)
maagfgrccrvlrsisrfhwrsqhtkanrqrepglgfsfefteqqkefqatarkfareei
ipvaaeydktgeypvplirrawelglmnthipencgglglgtfdacliseelaygctgvq
taiegnslgqmpiiiagndqqkkkylgrmteeplmcaycvtepgagsdvagiktkaekkg
deyiingqkmwitnggkanwyfllarsdpdpkapankaftgfiveadtpgiqigrkelnm
gqrcsdtrgivfedvkvpkenvligdgagfkvamgafdktrpvvaagavglaqraldeat
kyalerktfgkllvehqaisfmlaemamkvelarmsyqraawevdsgrrntyyasiakaf
agdianqlatdavqilggngfnteypveklmrdakiyqiyegtsqiqrlivarehidkyk
n

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tC (C:)
glgfsfefteqqkefqatarkfareeiipvaaeydktgeypvplirrawelglmnthipe
ncgglglgtfdacliseelaygctgvqtaiegnslgqmpiiiagndqqkkkylgrmteep
lmcaycvtepgagsdvagiktkaekkgdeyiingqkmwitnggkanwyfllarsdpdpka
pankaftgfiveadtpgiqigrkelnmgqrcsdtrgivfedvkvpkenvligdgagfkva
mgafdktrpvvaagavglaqraldeatkyalerktfgkllvehqaisfmlaemamkvela
rmsyqraawevdsgrrntyyasiakafagdianqlatdavqilggngfnteypveklmrd
akiyqiyegtsqiqrlivarehidkykn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2a1tD (D:)
maagfgrccrvlrsisrfhwrsqhtkanrqrepglgfsfefteqqkefqatarkfareei
ipvaaeydktgeypvplirrawelglmnthipencgglglgtfdacliseelaygctgvq
taiegnslgqmpiiiagndqqkkkylgrmteeplmcaycvtepgagsdvagiktkaekkg
deyiingqkmwitnggkanwyfllarsdpdpkapankaftgfiveadtpgiqigrkelnm
gqrcsdtrgivfedvkvpkenvligdgagfkvamgafdktrpvvaagavglaqraldeat
kyalerktfgkllvehqaisfmlaemamkvelarmsyqraawevdsgrrntyyasiakaf
agdianqlatdavqilggngfnteypveklmrdakiyqiyegtsqiqrlivarehidkyk
n

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tD (D:)
lgfsfefteqqkefqatarkfareeiipvaaeydktgeypvplirrawelglmnthipen
cgglglgtfdacliseelaygctgvqtaiegnslgqmpiiiagndqqkkkylgrmteepl
mcaycvtepgagsdvagiktkaekkgdeyiingqkmwitnggkanwyfllarsdpdpkap
ankaftgfiveadtpgiqigrkelnmgqrcsdtrgivfedvkvpkenvligdgagfkvam
gafdktrpvvaagavglaqraldeatkyalerktfgkllvehqaisfmlaemamkvelar
msyqraawevdsgrrntyyasiakafagdianqlatdavqilggngfnteypveklmrda
kiyqiyegtsqiqrlivarehidkykn

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >2a1tR (R:)
mfraaapgqlrraasllrfqstlviaehandslapitlntitaatrlggevsclvagtkc
dkvaqdlckvagiakvlvaqhdvykgllpeeltplilatqkqfnythicagasafgknll
prvaaklevapisdiiaikspdtfvrtiyagnalctvkcdekvkvfsvrgtsfdaaatsg
gsassekasstspveisewldqkltksdrpeltgakvvvsggrglksgenfkllydladq
lhaavgasraavdagfvpndmqvgqtgkivapelyiavgisgaiqhlagmkdsktivain
kdpeapifqvadygivadlfkvvpemteilkkk

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tR (R:)
rfqstlviaehandslapitlntitaatrlggevsclvagtkcdkvaqdlckvagiakvl
vaqhdvykgllpeeltplilatqkqfnythicagasafgknllprvaaklevapisdiia
ikspdtfvrtiyagnalctvkcdekvkvfsvrgtsfdaaatsggsassekasstspveis
ewldqkltrpeltgakvvvsggrglksgenfkllydladqlhaavgasraavdagfvpnd
mqvgqtgkivapelyiavgisgaiqhlagmkdsktivainkdpeapifqvadygivadlf
kvvpemteilkkk

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >2a1tS (S:)
maelrvlvavkrvidyavkirvkpdrtgvvtdgvkhsmnpfceiaveeavrlkekklvke
viavscgpaqcqetirtalamgadrgihvevppaeaerlgplqvarvlaklaekekvdlv
llgkqaidddcnqtgqmtagfldwpqgtfasqvtlegdklkveraidggletlrlklpav
vtadlrlnepryatlpnimkakkkkievikpgdlgvdltsklsvisvedppqrtagvkve
ttedlvaklkeigri

    Sequence, based on observed residues (ATOM records): (download) 
    >2a1tS (S:)
elrvlvavkrvidyavkirvkpdrtgvvtdgvkhsmnpfceiaveeavrlkekklvkevi
avscgpaqcqetirtalamgadrgihvevppaeaerlgplqvarvlaklaekekvdlvll
gkqaidddcnqtgqmtagfldwpqgtfasqvtlegdklkveraidggletlrlklpavvt
adlrlnepryatlpnimkakkkkievikpgdlgvdltsklsvisvedppttedlvaklk