PDB entry 2a1j

View 2a1j on RCSB PDB site
Description: Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1
Class: DNA binding protein
Keywords: XPF, ERCC1, Xeroderma pigmentosum, NER, DNA repair, endonuclease, helix-hairpin-helix
Deposited on 2005-06-20, released 2005-08-02
The last revision prior to the SCOP 1.75 freeze date was dated 2005-08-02, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.241
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA repair endonuclease XPF
    Species: HOMO SAPIENS
    Gene: ERCC4, ERCC11, XPF
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d2a1ja1
  • Chain 'B':
    Compound: DNA excision repair protein ERCC-1
    Species: HOMO SAPIENS
    Gene: ERCC1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07992 (14-90)
      • cloning artifact (12-13)
    Domains in SCOP 1.75: d2a1jb1
  • Heterogens: HG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2a1jA (A:)
    mpqdfllkmpgvnakncrslmhhvkniaelaalsqdeltsilgnaanakqlydfihtsfa
    evv
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a1jA (A:)
    pqdfllkmpgvnakncrslmhhvkniaelaalsqdeltsilgnaanakqlydfihtsfae
    vv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2a1jB (B:)
    mgsshhhhhhsqdpadllmekleqdfvsrvteclttvksvnktdsqtllttfgsleqlia
    asredlalcpglgpqkarrlfdvlhepflkv
    

    Sequence, based on observed residues (ATOM records): (download)
    >2a1jB (B:)
    dpadllmekleqdfvsrvteclttvksvnktdsqtllttfgsleqliaasredlalcpgl
    gpqkarrlfdvlhepflkv