PDB entry 2a19
View 2a19 on RCSB PDB site
Description: PKR kinase domain- eIF2alpha- AMP-PNP complex.
Class: protein synthesis/transferase
Keywords: transferase, kinase, protein biosynthesis, protein synthesis-transferase COMPLEX
Deposited on
2005-06-19, released
2005-09-27
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.234
AEROSPACI score: 0.28
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Eukaryotic translation initiation factor 2 alpha subunit
Species: Saccharomyces cerevisiae [TaxId:4932]
Gene: SUI2, TIF211
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2a19a1, d2a19a2, d2a19a3 - Chain 'B':
Compound: Interferon-induced, double-stranded RNA-activated protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: PRKR, EIF2AK2, PKR
Database cross-references and differences (RAF-indexed):
- Uniprot P19525 (3-270)
- cloning artifact (1-2)
- engineered (144)
- modified residue (178)
Domains in SCOPe 2.06: d2a19b1, d2a19b2 - Chain 'C':
Compound: Interferon-induced, double-stranded RNA-activated protein kinase
Species: Homo sapiens [TaxId:9606]
Gene: PRKR, EIF2AK2, PKR
Database cross-references and differences (RAF-indexed):
- Uniprot P19525 (3-270)
- cloning artifact (2)
- engineered (144)
Domains in SCOPe 2.06: d2a19c1, d2a19c2 - Heterogens: MG, PO4, ANP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2a19A (A:)
gsshcrfyenkypeiddivmvnvqqiaemgayvklleydniegmillselsrrrirsiqk
lirvgkndvavvlrvdkekgyidlskrrvssediikceekyqksktvhsilrycaekfqi
pleelyktiawplsrkfghayeafklsiidetvwegieppskdvldelknyiskr
Sequence, based on observed residues (ATOM records): (download)
>2a19A (A:)
sshcrfyenkypeiddivmvnvqqiaemgayvklleydniegmillssiqklirvgkndv
avvlrvdkekgyidlskrrvssediikceekyqksktvhsilrycaekfqipleelykti
awplsrkfghayeafklsiidetvwegieppskdvldelknyisk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2a19B (B:)
gahtvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalak
ldhvnivhyngcwdgfdydpetssknssrsktkclfiqmefcdkgtleqwiekrrgekld
kvlalelfeqitkgvdyihskklinrdlkpsniflvdtkqvkigdfglvtslkndgkrtr
skgtlrymspeqissqdygkevdlyalglilaellhvcdtafetskfftdlrdgiisdif
dkkektllqkllskkpedrpntseilrtltvwkkspeknerhta
Sequence, based on observed residues (ATOM records): (download)
>2a19B (B:)
ahtvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalakl
dhvnivhyngcwdgfdydrsktkclfiqmefcdkgtleqwiekrrgekldkvlalelfeq
itkgvdyihskklinrdlkpsniflvdtkqvkigdfglvtslkndgkrtrskgtlrymsp
eqissqdygkevdlyalglilaellhvcdtafetskfftdlrdgiisdifdkkektllqk
llskkpedrpntseilrtltvwkk
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2a19C (C:)
gahtvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalak
ldhvnivhyngcwdgfdydpetssknssrsktkclfiqmefcdkgtleqwiekrrgekld
kvlalelfeqitkgvdyihskklinrdlkpsniflvdtkqvkigdfglvtslkndgkrtr
skgtlrymspeqissqdygkevdlyalglilaellhvcdtafetskfftdlrdgiisdif
dkkektllqkllskkpedrpntseilrtltvwkkspeknerhta
Sequence, based on observed residues (ATOM records): (download)
>2a19C (C:)
htvdkrfgmdfkeieligsggfgqvfkakhridgktyvikrvkynnekaerevkalakld
hvnivhyngcwdgfdydpetsktkclfiqmefcdkgtllalelfeqitkgvdyihskkli
nrdlkpsniflvdtkqvkigdfglvgkevdlyalglilaellgiisdifdkkektllqkl
lskkpedrpntseilrtltvwkk