PDB entry 1z8a
View 1z8a on RCSB PDB site
Description: Human Aldose Reductase complexed with novel Sulfonyl-pyridazinone Inhibitor
Class: oxidoreductase
Keywords: Protein-Ligand complex, TIM-barrel, double conformation
Deposited on
2005-03-30, released
2006-03-14
The last revision prior to the SCOP 1.73 freeze date was dated
2006-03-14, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 0.95 Å
R-factor: 0.122
AEROSPACI score: 0.93
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: aldose reductase
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d1z8aa1 - Heterogens: NAP, 62P, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1z8aA (A:)
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef
Sequence, based on observed residues (ATOM records): (download)
>1z8aA (A:)
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef