PDB entry 1z3u

View 1z3u on RCSB PDB site
Description: Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition
Class: signaling protein
Keywords: Tie2 binding, angiogenesis, extracellular ligand, SIGNALING PROTEIN
Deposited on 2005-03-14, released 2005-07-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.246
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Angiopoietin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15123 (1-End)
      • cloning artifact (0)
      • engineered (189)
      • engineered (195-196)
    Domains in SCOPe 2.08: d1z3ua1, d1z3ua2
  • Chain 'B':
    Compound: Angiopoietin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15123 (1-End)
      • cloning artifact (0)
      • engineered (189)
      • engineered (195-196)
    Domains in SCOPe 2.08: d1z3ub1, d1z3ub2
  • Chain 'C':
    Compound: Angiopoietin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15123 (1-End)
      • cloning artifact (0)
      • engineered (189)
      • engineered (195-196)
    Domains in SCOPe 2.08: d1z3uc1, d1z3uc2
  • Chain 'D':
    Compound: Angiopoietin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15123 (1-End)
      • cloning artifact (0)
      • engineered (189)
      • engineered (195-196)
    Domains in SCOPe 2.08: d1z3ud1, d1z3ud2
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1z3uA (A:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpadf

    Sequence, based on observed residues (ATOM records): (download) 
    >1z3uA (A:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpad

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1z3uB (B:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpadf

    Sequence, based on observed residues (ATOM records): (download) 
    >1z3uB (B:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpad

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1z3uC (C:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpadf

    Sequence, based on observed residues (ATOM records): (download) 
    >1z3uC (C:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpad

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1z3uD (D:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpadf

    Sequence, based on observed residues (ATOM records): (download) 
    >1z3uD (D:)
sfrdcaevfksghttngiytltfpnsteeikaycdmeaggggwtiiqrredgsvdfqrtw
keykvgfgnpsgeywlgnefvsqltnqqryvlkihlkdwegneayslyehfylsseelny
rihlkgltgtagkissisqpgndfstkdgdndkcickcsqmltggwwfdacgpsnlngmy
ypqrqntnkangikwaawkgsgyslkattmmirpad