PDB entry 1yy9

View 1yy9 on RCSB PDB site
Description: Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Class: IMMUNE SYSTEM/Transferase
Keywords: CELL SURFACE RECEPTOR; TYROSINE KINASE; GLYCOPROTEIN; ANTIGEN:ANTIBODY COMPLEX; FAB FRAGMENT; ANTITUMOR; DRUG, IMMUNE SYSTEM-Transferase complex
Deposited on 2005-02-24, released 2005-04-26
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.242
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (473)
      • conflict (609)
    Domains in SCOPe 2.03: d1yy9a1, d1yy9a2, d1yy9a3, d1yy9a4
  • Chain 'C':
    Compound: Cetuximab Fab Light chain
    Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY9 (0-End)
    Domains in SCOPe 2.03: d1yy9c1, d1yy9c2
  • Chain 'D':
    Compound: Cetuximab Fab Heavy chain
    Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY9 (0-End)
  • Heterogens: NDG, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1yy9A (A:)
leekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqe
vagyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeil
hgavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgage
encqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtc
pplmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvr
kckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsftht
ppldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvsln
itslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgq
vchalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclp
qamnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnc
tygctgpglrgcptngpkhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >1yy9A (A:)
eekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqev
agyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeilh
gavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgagee
ncqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtcp
plmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvrk
ckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtp
pldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslni
tslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgqv
chalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclpq
amnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnct
ygctgpglrgcpt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1yy9C (C:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrga

    Sequence, based on observed residues (ATOM records): (download) 
    >1yy9C (C:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'D':
    No sequence available.