PDB entry 1yy9

View 1yy9 on RCSB PDB site
Description: Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Class: IMMUNE SYSTEM/Transferase
Keywords: CELL SURFACE RECEPTOR; TYROSINE KINASE; GLYCOPROTEIN; ANTIGEN:ANTIBODY COMPLEX; FAB FRAGMENT; ANTITUMOR; DRUG, IMMUNE SYSTEM-Transferase complex
Deposited on 2005-02-24, released 2005-04-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.242
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • conflict (473)
      • conflict (609)
    Domains in SCOPe 2.07: d1yy9a1, d1yy9a2, d1yy9a3, d1yy9a4, d1yy9a5
  • Chain 'C':
    Compound: Cetuximab Fab Light chain
    Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY9 (0-End)
    Domains in SCOPe 2.07: d1yy9c1, d1yy9c2
  • Chain 'D':
    Compound: Cetuximab Fab Heavy chain
    Species: Mus musculus, Homo sapiens [TaxId:10090,9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 1YY9 (0-End)
  • Heterogens: NDG, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1yy9A (A:)
    leekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqe
    vagyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeil
    hgavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgage
    encqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtc
    pplmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvr
    kckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsftht
    ppldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvsln
    itslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgq
    vchalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclp
    qamnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnc
    tygctgpglrgcptngpkhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >1yy9A (A:)
    eekkvcqgtsnkltqlgtfedhflslqrmfnncevvlgnleityvqrnydlsflktiqev
    agyvlialntveriplenlqiirgnmyyensyalavlsnydanktglkelpmrnlqeilh
    gavrfsnnpalcnvesiqwrdivssdflsnmsmdfqnhlgscqkcdpscpngscwgagee
    ncqkltkiicaqqcsgrcrgkspsdcchnqcaagctgpresdclvcrkfrdeatckdtcp
    plmlynpttyqmdvnpegkysfgatcvkkcprnyvvtdhgscvracgadsyemeedgvrk
    ckkcegpcrkvcngigigefkdslsinatnikhfknctsisgdlhilpvafrgdsfthtp
    pldpqeldilktvkeitgflliqawpenrtdlhafenleiirgrtkqhgqfslavvslni
    tslglrslkeisdgdviisgnknlcyantinwkklfgtsgqktkiisnrgenkckatgqv
    chalcspegcwgpeprdcvscrnvsrgrecvdkckllegeprefvenseciqchpeclpq
    amnitctgrgpdnciqcahyidgphcvktcpagvmgenntlvwkyadaghvchlchpnct
    ygctgpglrgcpt
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1yy9C (C:)
    dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
    rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnrga
    

    Sequence, based on observed residues (ATOM records): (download)
    >1yy9C (C:)
    dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
    rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
    sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
    lskadyekhkvyacevthqglsspvtksfnr
    

  • Chain 'D':
    No sequence available.