PDB entry 1ywh

View 1ywh on RCSB PDB site
Description: crystal structure of urokinase plasminogen activator receptor
Class: hydrolase receptor
Keywords: uPAR, three-finger fold, protein-peptide complex, HYDROLASE RECEPTOR
Deposited on 2005-02-18, released 2005-05-10
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.249
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywha1, d1ywha2, d1ywha3
  • Chain 'B':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'C':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhc1, d1ywhc2, d1ywhc3
  • Chain 'D':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'E':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhe1, d1ywhe2, d1ywhe3
  • Chain 'F':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'G':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhg1, d1ywhg2, d1ywhg3
  • Chain 'H':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'I':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhi1, d1ywhi2, d1ywhi3
  • Chain 'J':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'K':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhk1, d1ywhk2, d1ywhk3
  • Chain 'L':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'M':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywhm1, d1ywhm2, d1ywhm3
  • Chain 'N':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Chain 'O':
    Compound: Urokinase plasminogen activator surface receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PLAUR, MO3, UPAR
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UMV0 (0-End)
      • conflict (199)
    Domains in SCOPe 2.06: d1ywho1, d1ywho2, d1ywho3
  • Chain 'P':
    Compound: antagonist peptide
    Database cross-references and differences (RAF-indexed):
    • PDB 1YWH (0-12)
  • Heterogens: NDG, NAG, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1ywhA (A:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhA (A:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgrsryleciscgssdmscergrhqslqcrspeeqcldvv
thwiqrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqng
rqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhah
lgdafsmnhidvscctksgcnhpdldvq

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1ywhC (C:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhC (C:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnryleciscgssdmscergrhqslqcrspeeqcldvvthwi
qpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcys
ckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdaf
smnhidvscctksgcnhpd

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1ywhE (E:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhE (E:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgrsryleciscgssdmscergrhqslqcrspeeqcldvvthw
iqkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcys
ckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdaf
smnhidvscctksgcnhpdldv

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1ywhG (G:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhG (G:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgyleciscgssdmscergrhqslqcrspeeqcldvvthwiqe
kddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcysck
gqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdafsm
nhidvscctksgcnhpdl

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1ywhI (I:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhI (I:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravyleciscgssdmscergrhqslqcrspeeqcldvv
thwiqrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqng
rqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhah
lgdafsmnhidvscctksgcnhpd

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1ywhK (K:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhK (K:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqsryleciscgssdmscergrhqslqcrspeeqcldvvthwik
ddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcysckg
qsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdafsmn
hidvscctksgcnhpdl

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    Sequence, based on SEQRES records: (download) 
    >1ywhM (M:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhM (M:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnssrsryleciscgssdmscergrhqslqcrspeeqcldvv
thwiqddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqc
ysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgd
afsmnhidvscctksgcnhpdld

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    Sequence, based on SEQRES records: (download) 
    >1ywhO (O:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsgravtysrsryleciscgssdmscergrhqslqcrspee
qcldvvthwiqegeegrpkddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegp
ilelenlpqngrqcysckgqsthgcsseetflidcrgpmnqclvatgthepknqsymvrg
catasmcqhahlgdafsmnhidvscctksgcnhpdldvqyrsgaapqpgpahlsltitll
mtarlwggtllwt

    Sequence, based on observed residues (ATOM records): (download) 
    >1ywhO (O:)
lrcmqcktngdcrveecalgqdlcrttivrlweegeelelvekscthsektnrtlsyrtg
lkitsltevvcgldlcnqgnsyleciscgssdmscergrhqslqcrspeeqcldvvthwi
qddrhlrgcgylpgcpgsngfhnndtfhflkccnttkcnegpilelenlpqngrqcysck
gqsthgcsseetflidcrgpmnqclvatgthepknqsymvrgcatasmcqhahlgdafsm
nhidvscctksgcnhpdl

  • Chain 'P':
    No sequence available.