SCOP 1.75: Structural Classification of Proteins

PDB entry 1xqc

View 1xqc on RCSB PDB site
Description: X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution
Class: HORMONE receptor
Keywords: alpha-helical sandwich, nuclear hormone receptor, ligand binding domain
Deposited on 2004-10-12, released 2005-02-01
The last revision prior to the SCOP 1.75 freeze date was dated 2005-02-01, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.213
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Estrogen receptor
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered (81)
  - engineered (117)
Domains in SCOP 1.75: d1xqca1
Chain 'B':
Compound: Estrogen receptor
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered (81)
  - engineered (117)
Domains in SCOP 1.75: d1xqcb1
Chain 'C':
Compound: Estrogen receptor
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered (81)
  - engineered (117)
Domains in SCOP 1.75: d1xqcc1
Chain 'D':
Compound: Estrogen receptor
Species: HOMO SAPIENS
Database cross-references and differences (RAF-indexed):
- Uniprot P03372
  - engineered (81)
  - engineered (117)
Domains in SCOP 1.75: d1xqcd1
Heterogens: AEJ, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>1xqcA (A:)
mskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydl
llemldahrlhapt

Sequence, based on observed residues (ATOM records): (download)

>1xqcA (A:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlysmplydlllemldahr

Chain 'B':
Sequence, based on SEQRES records: (download)

>1xqcB (B:)
mskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydl
llemldahrlhapt

Sequence, based on observed residues (ATOM records): (download)

>1xqcB (B:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlplydlllemldahr

Chain 'C':
Sequence, based on SEQRES records: (download)

>1xqcC (C:)
mskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydl
llemldahrlhapt

Sequence, based on observed residues (ATOM records): (download)

>1xqcC (C:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlysmplydlllemldahr

Chain 'D':
Sequence, based on SEQRES records: (download)

>1xqcD (D:)
mskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhmin
wakrvpgfvdltlhdqvhllesawleilmiglvwrsmehpgkllfapnllldrnqgksve
gmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihrvl
dkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmksknvvplydl
llemldahrlhapt

Sequence, based on observed residues (ATOM records): (download)

>1xqcD (D:)
alsltadqmvsalldaeppilysesmmglltnladrelvhminwakrvpgfvdltlhdqv
hllesawleilmiglvwrsmehpgkllfapnllldrnqgksvegmveifdmllatssrfr
mmnlqgeefvclksiillnsgvytfstlksleekdhihrvldkitdtlihlmakagltlq
qqhqrlaqlllilshirhmsnkgmehlplydlllemldahr