PDB entry 1xoz
View 1xoz on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
Class: hydrolase
Keywords: Phosphodiesterase, PDE, PDE5A, Tadalafil, Cialis, HYDROLASE
Deposited on
2004-10-07, released
2004-12-14
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: 0.154
AEROSPACI score: 0.75
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
Species: Homo sapiens [TaxId:9606]
Gene: PDE5A, PDE5
Database cross-references and differences (RAF-indexed):
- Uniprot O76074 (21-End)
- engineered (145)
- engineered (148)
- engineered (150)
- engineered (134-135)
- engineered (154-158)
- engineered (161-163)
- engineered (165-166)
- engineered (168-169)
Domains in SCOPe 2.05: d1xoza_ - Heterogens: ZN, MG, CIA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1xozA (A:)
mgsshhhhhhssglvprgshmeeetrelqslaaavvpsaqtlkitdfsfsdfelsdleta
lctirmftdlnlvqnfqmkhevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkag
kiqnkltdleilalliaalshdldhpgvsnqflintnselalmyndesvlehhhfdqclm
ilnspgnqilsglsieeykttlkiikqailatdlalyikrrgeffelirknqfnledphq
kelflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkelnieptdlmnrekkn
kipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqqekmlingesgq
akrn
Sequence, based on observed residues (ATOM records): (download)
>1xozA (A:)
eeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeyktt
lkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpw
piqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyeal
thvsedcfplldgcrknrqkwqalae