PDB entry 1xoz

View 1xoz on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
Class: hydrolase
Keywords: Phosphodiesterase, PDE, PDE5A, Tadalafil, Cialis, HYDROLASE
Deposited on 2004-10-07, released 2004-12-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.37 Å
R-factor: 0.154
AEROSPACI score: 0.75 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76074 (21-End)
      • engineered (145)
      • engineered (148)
      • engineered (150)
      • engineered (134-135)
      • engineered (154-158)
      • engineered (161-163)
      • engineered (165-166)
      • engineered (168-169)
    Domains in SCOPe 2.07: d1xoza_
  • Heterogens: ZN, MG, CIA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1xozA (A:)
    mgsshhhhhhssglvprgshmeeetrelqslaaavvpsaqtlkitdfsfsdfelsdleta
    lctirmftdlnlvqnfqmkhevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkag
    kiqnkltdleilalliaalshdldhpgvsnqflintnselalmyndesvlehhhfdqclm
    ilnspgnqilsglsieeykttlkiikqailatdlalyikrrgeffelirknqfnledphq
    kelflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkelnieptdlmnrekkn
    kipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqqekmlingesgq
    akrn
    

    Sequence, based on observed residues (ATOM records): (download)
    >1xozA (A:)
    eeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
    vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
    dldhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeyktt
    lkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpw
    piqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyeal
    thvsedcfplldgcrknrqkwqalae