PDB entry 1xos

View 1xos on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil
Class: hydrolase
Keywords: Phosphodiesterase, PDE, PDE4B, Sildenafil, Viagra, HYDROLASE
Deposited on 2004-10-06, released 2004-12-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.28 Å
R-factor: 0.212
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07343
      • modified residue (63)
      • modified residue (189)
      • modified residue (301)
    Domains in SCOPe 2.07: d1xosa_
  • Heterogens: ZN, MG, SO4, VIA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >1xosA (A:)
    mgsshhhhhhssglvprgshmsisrfgvntenedhlakeledlnkwglnifnvagyshnr
    pltcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvll
    stpaldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
    gfkllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssg
    vllldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeisp
    mcdkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsp
    pldeqnrdcqglmekfqfeltldeedsegpekegeghs
    

    Sequence, based on observed residues (ATOM records): (download)
    >1xosA (A:)
    nedhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymm
    tledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgv
    snqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidm
    vlatdmskhmslladlktmvetkkvtgvllldnytdriqvlrnmvhcadlsnptkslely
    rqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlvq
    pdaqdildtlednrnwyqsmip