PDB entry 1xlx

View 1xlx on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast
Class: hydrolase
Keywords: PDE4B, Cilomilast, HYDROLASE
Deposited on 2004-09-30, released 2004-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: 0.235
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07343
      • modified residue (63)
    Domains in SCOPe 2.08: d1xlxa_
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4B
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07343
      • modified residue (63)
    Domains in SCOPe 2.08: d1xlxb_
  • Heterogens: ZN, MG, CIO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xlxA (A:)
mgsshhhhhhssglvprgshmsisrfgvntenedhlakeledlnkwglnifnvagyshnr
pltcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvll
stpaldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
gfkllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssg
vllldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeisp
mcdkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsp
pldeqnrdcqglmekfqfeltldeedsegpekegeghs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xlxA (A:)
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmip

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xlxB (B:)
mgsshhhhhhssglvprgshmsisrfgvntenedhlakeledlnkwglnifnvagyshnr
pltcimyaifqerdllktfrissdtfitymmtledhyhsdvayhnslhaadvaqsthvll
stpaldavftdleilaaifaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
gfkllqeehcdifmnltkkqrqtlrkmvidmvlatdmskhmslladlktmvetkkvtssg
vllldnytdriqvlrnmvhcadlsnptkslelyrqwtdrimeeffqqgdkerergmeisp
mcdkhtasveksqvgfidyivhplwetwadlvqpdaqdildtlednrnwyqsmipqspsp
pldeqnrdcqglmekfqfeltldeedsegpekegeghs

    Sequence, based on observed residues (ATOM records): (download) 
    >1xlxB (B:)
edhlakeledlnkwglnifnvagyshnrpltcimyaifqerdllktfrissdtfitymmt
ledhyhsdvayhnslhaadvaqsthvllstpaldavftdleilaaifaaaihdvdhpgvs
nqflintnselalmyndesvlenhhlavgfkllqeehcdifmnltkkqrqtlrkmvidmv
latdmskhmslladlktmvetkkvtssgvllldnytdriqvlrnmvhcadlsnptkslel
yrqwtdrimeeffqqgdkerergmeispmcdkhtasveksqvgfidyivhplwetwadlv
qpdaqdildtlednrnwyqsmip