PDB entry 1xd2

View 1xd2 on RCSB PDB site
Description: Crystal Structure of a ternary Ras:SOS:Ras*GDP complex
Class: signaling protein
Keywords: Ras:SOS complex, Ras-nucleotide exchange factor complex, SIGNALING PROTEIN
Deposited on 2004-09-03, released 2004-11-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.212
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: transforming protein p21/h-ras-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (0-165)
      • engineered (63)
    Domains in SCOPe 2.06: d1xd2a_
  • Chain 'B':
    Compound: transforming protein p21/h-ras-1
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1xd2b_
  • Chain 'C':
    Compound: Son of sevenless protein homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d1xd2c_
  • Heterogens: MG, PO4, GDP

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1xd2A (A:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >1xd2B (B:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >1xd2C (C:)
    qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
    tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
    qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
    ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
    gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
    nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
    cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
    dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
    rpgt
    

    Sequence, based on observed residues (ATOM records): (download)
    >1xd2C (C:)
    qmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltty
    rsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvln
    vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiahnitfqss
    pptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkein
    spnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsa
    mnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltni
    lkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpm
    gnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr