PDB entry 1xbt

View 1xbt on RCSB PDB site
Description: Crystal Structure of Human Thymidine Kinase 1
Class: Transferase
Keywords: DEOXYRIBONUCLEOSIDE KINASE, ZINC-BINDING DOMAIN, FEEDBACK INHIBITOR, Transferase
Deposited on 2004-08-31, released 2004-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.203
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbta1, d1xbta2
  • Chain 'B':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbtb1, d1xbtb2
  • Chain 'C':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbtc1, d1xbtc2
  • Chain 'D':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbtd1, d1xbtd2
  • Chain 'E':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbte1, d1xbte2
  • Chain 'F':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbtf1, d1xbtf2
  • Chain 'G':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbtg1, d1xbtg2
  • Chain 'H':
    Compound: Thymidine kinase, cytosolic
    Species: Homo sapiens [TaxId:9606]
    Gene: TK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d1xbth1, d1xbth2
  • Heterogens: ZN, MG, TTP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1xbtA (A:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtA (A:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklta
vcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1xbtB (B:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtB (B:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklta
vcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1xbtC (C:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtC (C:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklta
vcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1xbtD (D:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtD (D:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysalpacllrdvaqeal
gvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvkl
tavcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1xbtE (E:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtE (E:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklta
vcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1xbtF (F:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtF (F:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtralpacllrdvaqealgv
avigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklta
vcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfkk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1xbtG (G:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtG (G:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtrysssealpacllrdvaq
ealgvavigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesv
vkltavcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1xbtH (H:)
mscinlptvlpgspsktrgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtr
ysssfcthdrntmealpacllrdvaqealgvavigidegqffpdivefceamanagktvi
vaaldgtfqrkpfgailnlvplaesvvkltavcmecfreaaytkrlgtekeveviggadk
yhsvcrlcyfkka

    Sequence, based on observed residues (ATOM records): (download) 
    >1xbtH (H:)
rgqiqvilgpmfsgkstelmrrvrrfqiaqykclvikyakdtryalpacllrdvaqealg
vavigidegqffpdivefceamanagktvivaaldgtfqrkpfgailnlvplaesvvklt
avcmecfreaaytkrlgtekeveviggadkyhsvcrlcyfk