PDB entry 1xbb
View 1xbb on RCSB PDB site
Description: Crystal structure of the syk tyrosine kinase domain with Gleevec
Class: Transferase
Keywords: Gleevec, STI-571, Imatinib, SYK, spleen typrosine kinase, active conformation, structural genomics, Structural GenomiX, Transferase
Deposited on
2004-08-30, released
2004-11-02
The last revision prior to the SCOPe 2.02 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.57 Å
R-factor: 0.191
AEROSPACI score: 0.61
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase SYK
Species: Homo sapiens [TaxId:9606]
Gene: SYK
Database cross-references and differences (RAF-indexed):
- Uniprot P43405 (Start-282)
- cloning artifact (283-284)
- expression tag (285-286)
Domains in SCOPe 2.02: d1xbba_ - Heterogens: STI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>1xbbA (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvneghhhhhh
Sequence, based on observed residues (ATOM records): (download)
>1xbbA (A:)
vyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqql
dnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvkdkniielvhqvsmgmkylee
snfvhrdlaarnvllvtqhyakisdfglskalradenyykakwpvkwyapecinyykfss
ksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcwty
dvenrpgfaavelrlrnyyydvvneghh