PDB entry 1wzi

View 1wzi on RCSB PDB site
Description: Structural basis for alteration of cofactor specificity of Malate dehydrogenase from Thermus flavus
Class: oxidoreductase
Keywords: Seven amino acid residues mutant, protein-NADPH complex, OXIDOREDUCTASE
Deposited on 2005-03-05, released 2006-03-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.196
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: malate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Gene: MDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10584 (0-326)
      • engineered (41-47)
    Domains in SCOPe 2.06: d1wzia1, d1wzia2
  • Chain 'B':
    Compound: malate dehydrogenase
    Species: Thermus thermophilus [TaxId:274]
    Gene: MDH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10584 (0-326)
      • engineered (41-47)
    Domains in SCOPe 2.06: d1wzib1, d1wzib2
  • Heterogens: NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wziA (A:)
mkapvrvavtgaagqigysllfriaagemlgkdqpvilqllgsersfqalegvvmeledc
afpllagleatddpkvafkdadyallvgaaprkagmerrdllqvngkifteqgralaeva
kkdvkvlvvgnpantnaliayknapglnprnftamtrldhnrakaqlakktgtgvdrirr
mtvwgnhsstmfpdlfhaevdgrpalelvdmewyekvfiptvaqrgaaiiqargassaas
aanaaiehirdwalgtpegdwvsmavpsqgeygipegivysfpvtakdgayrvveglein
efarkrmeitaqelldemeqvkalgli

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1wziB (B:)
mkapvrvavtgaagqigysllfriaagemlgkdqpvilqllgsersfqalegvvmeledc
afpllagleatddpkvafkdadyallvgaaprkagmerrdllqvngkifteqgralaeva
kkdvkvlvvgnpantnaliayknapglnprnftamtrldhnrakaqlakktgtgvdrirr
mtvwgnhsstmfpdlfhaevdgrpalelvdmewyekvfiptvaqrgaaiiqargassaas
aanaaiehirdwalgtpegdwvsmavpsqgeygipegivysfpvtakdgayrvveglein
efarkrmeitaqelldemeqvkalgli