PDB entry 1wci

View 1wci on RCSB PDB site
Description: reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
Class: oxidoreductase
Keywords: oxidoreductase, ketoacid dehydrogenase, branched-chain,multi enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine diphosphate, phosphorylation, conformational switch, reactivity, flavoprotein, maple syru urine disease, mitochondrion, thiamine
Deposited on 2004-11-16, released 2006-02-16
The last revision prior to the SCOP 1.73 freeze date was dated 2006-02-16, with a file datestamp of 2007-06-28.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: 0.14872
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 2-oxoisovalerate dehydrogenase alpha subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1wcia1
  • Chain 'B':
    Compound: 2-oxoisovalerate dehydrogenase beta subunit
    Species: HOMO SAPIENS
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1wcib1, d1wcib2
  • Heterogens: CL, K, MN, WWF, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1wciA (A:)
sslddkpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlkl
yksmtllntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlm
yrdyplelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakr
ananrvvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgia
argpgygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssay
rsvdevnywdkqdhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnp
nllfsdvyqempaqlrkqqeslarhlqtygehypldhfdk

    Sequence, based on observed residues (ATOM records): (download) 
    >1wciA (A:)
kpqfpgasaefidklefiqpnvisgipiyrvmdrqgqiinpsedphlpkekvlklyksmt
llntmdrilyesqrqgrisfymtnygeegthvgsaaaldntdlvfgqyreagvlmyrdyp
lelfmaqcygnisdlgkgrqmpvhygckerhfvtissplatqipqavgaayaakrananr
vvicyfgegaasegdahagfnfaatlecpiiffcrnngyaistptseqyrgdgiaargpg
ygimsirvdgndvfavynatkearrravaenqpflieamtyrighhstsddssayrwdkq
dhpisrlrhyllsqgwwdeeqekawrkqsrrkvmeafeqaerkpkpnpnllfsdvyqemp
aqlrkqqeslarhlqtygehypldhfdk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1wciB (B:)
vahftfqpdpepreygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvgl
rdkygkdrvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryr
sgdlfncgsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllscie
dknpciffepkilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasm
akeklgvscevidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecf
lnleapisrvcgydtpfphifepfyipdkwkcydalrkminy

    Sequence, based on observed residues (ATOM records): (download) 
    >1wciB (B:)
ahftfqeygqtqkmnlfqsvtsaldnslakdptavifgedvafggvfrctvglrdkygkd
rvfntplceqgivgfgigiavtgataiaeiqfadyifpafdqivneaakyryrsgdlfnc
gsltirspwgcvghgalyhsqspeaffahcpgikvviprspfqakglllsciedknpcif
fepkilyraaaeevpiepyniplsqaeviqegsdvtlvawgtqvhvirevasmakeklgv
scevidlrtiipwdvdticksviktgrllisheapltggfaseisstvqeecflnleapi
srvcgydtpfphifepfyipdkwkcydalrkminy