PDB entry 1unl

View 1unl on RCSB PDB site
Description: structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin.
Class: cyclin dependent kinase
Keywords: cyclin dependent kinase, inhibitor, ATP-analogue, neurodegenerative diseases
Deposited on 2003-09-10, released 2004-11-10
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.216
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00535 (0-291)
      • engineered mutation (143)
    Domains in SCOPe 2.03: d1unla_
  • Chain 'B':
    Compound: cyclin-dependent kinase 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00535 (0-291)
      • engineered mutation (143)
    Domains in SCOPe 2.03: d1unlb_
  • Chain 'D':
    Compound: Cyclin-dependent kinase 5 activator 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1unld_
  • Chain 'E':
    Compound: Cyclin-dependent kinase 5 activator 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1unle_
  • Heterogens: RRC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1unlA (A:)
mqkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkh
knivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsr
nvlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklys
tsidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpyp
mypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsdfcpp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1unlB (B:)
mqkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkh
knivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsr
nvlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklys
tsidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpyp
mypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsdfcpp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1unlD (D:)
qpppaqppappasqlsgsqtggsssvkkaphpavtsagtpkrvivqastsellrclgefl
crrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflymlcrdvissevgsd
helqavlltclylsysymgneisyplkpflvesckeafwdrclsvinlmsskmlqinadp
hyftqvfsdlknesgqedkkrlllgldr

    Sequence, based on observed residues (ATOM records): (download) 
    >1unlD (D:)
qastsellrclgeflcrrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvfl
ymlcrdvissevgsdhelqavlltclylsysymgneisyplkpflvesckeafwdrclsv
inlmsskmlqinadphyftqvfsdlknesg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1unlE (E:)
qpppaqppappasqlsgsqtggsssvkkaphpavtsagtpkrvivqastsellrclgefl
crrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflymlcrdvissevgsd
helqavlltclylsysymgneisyplkpflvesckeafwdrclsvinlmsskmlqinadp
hyftqvfsdlknesgqedkkrlllgldr

    Sequence, based on observed residues (ATOM records): (download) 
    >1unlE (E:)
qastsellrclgeflcrrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvfl
ymlcrdvissevgsdhelqavlltclylsysymgneisyplkpflvesckeafwdrclsv
inlmsskmlqinadphyftqvfsdlknesg