PDB entry 1unh

View 1unh on RCSB PDB site
Description: structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
Class: cell cycle
Keywords: cell cycle, neurodegenerative diseases, indirubin
Deposited on 2003-09-10, released 2004-11-10
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: 0.229
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-dependent kinase 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00535
      • engineered mutation (143)
    Domains in SCOPe 2.03: d1unha_
  • Chain 'B':
    Compound: cyclin-dependent kinase 5
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00535
      • engineered mutation (143)
    Domains in SCOPe 2.03: d1unhb_
  • Chain 'D':
    Compound: Cyclin-dependent kinase 5 activator 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1unhd_
  • Chain 'E':
    Compound: Cyclin-dependent kinase 5 activator 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1unhe_
  • Heterogens: IXM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1unhA (A:)
mqkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkh
knivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsr
nvlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklys
tsidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpyp
mypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsdfcpp

    Sequence, based on observed residues (ATOM records): (download) 
    >1unhA (A:)
qkyeklekiygtvfkaknrheivalkrvrldgvpssalreicllkelkhknivrlhdvlh
sdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrnvlhrdlkpqn
llinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklystsidmwsagci
faelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypmypattslvnv
vpklnatgrdllqnllkcnpvqrisaeealqhpyfsd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1unhB (B:)
mqkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkh
knivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsr
nvlhrdlkpqnllinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklys
tsidmwsagcifaelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpyp
mypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfsdfcpp

    Sequence, based on observed residues (ATOM records): (download) 
    >1unhB (B:)
qkyeklekiygtvfkaknrheivalkrvrldgvpssalreicllkelkhknivrlhdvlh
sdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrnvlhrdlkpqn
llinrngelklanfglarafgipvrcysaevvtlwyrppdvlfgaklystsidmwsagci
faelanagrplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypmypattslvnv
vpklnatgrdllqnllkcnpvqrisaeealqhpyfsd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1unhD (D:)
qpppaqppappasqlsgsqtggsssvkkaphpavtsagtpkrvivqastsellrclgefl
crrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflymlcrdvissevgsd
helqavlltclylsysymgneisyplkpflvesckeafwdrclsvinlmsskmlqinadp
hyftqvfsdlknesgqedkkrlllgldr

    Sequence, based on observed residues (ATOM records): (download) 
    >1unhD (D:)
stsellrclgeflcrrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflym
lcrdvissevgsdhelqavlltclylsysymgneisyplkpflvesckeafwdrclsvin
lmsskmlqinadphyftqvfsdlknesg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1unhE (E:)
qpppaqppappasqlsgsqtggsssvkkaphpavtsagtpkrvivqastsellrclgefl
crrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflymlcrdvissevgsd
helqavlltclylsysymgneisyplkpflvesckeafwdrclsvinlmsskmlqinadp
hyftqvfsdlknesgqedkkrlllgldr

    Sequence, based on observed residues (ATOM records): (download) 
    >1unhE (E:)
stsellrclgeflcrrcyrlkhlsptdpvlwlrsvdrslllqgwqdqgfitpanvvflym
lcrdvissevgsdhelqavlltclylsysymgneisyplkpflvesckeafwdrclsvin
lmsskmlqinadphyftqvfsdlknesg