PDB entry 1ty6

View 1ty6 on RCSB PDB site
Description: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Class: cell adhesion/immune system
Keywords: crystal structure; platelet integrin alphaIIBbeta3; fibrinogen binding; allostery; therapeutic antagonism
Deposited on 2004-07-07, released 2004-10-12
The last revision prior to the SCOP 1.73 freeze date was dated 2004-11-09, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.2
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: integrin alpha-IIb
    Species: HOMO SAPIENS
    Gene: ITGAB
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1ty6a_
  • Chain 'B':
    Compound: integrin beta-3
    Species: HOMO SAPIENS
    Gene: ITGAB
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.73: d1ty6b1, d1ty6b2, d1ty6b3
  • Chain 'H':
    Compound: monoclonal antibody 10e5 heavy chain
    Species: Mus musculus
    Domains in SCOP 1.73: d1ty6h1, d1ty6h2
  • Chain 'L':
    Compound: monoclonal antibody 10e5 light chain
    Species: Mus musculus
    Domains in SCOP 1.73: d1ty6l1, d1ty6l2
  • Chain 'X':
    Compound: eptifibatide
  • Heterogens: NAG, NDG, MG, CA, NH2, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1ty6A (A:)
lnldpvqltfyagpngsqfgfsldfhkdshgrvaivvgaprtlgpsqeetggvflcpwra
eggqcpsllfdlrdetrnvgsqtlqtfkarqglgasvvswsdvivacapwqhwnvlekte
eaektpvgscflaqpesgrraeyspcrgntlsriyvendfswdkryceagfssvvtqage
lvlgapggyyflgllaqapvadifssyrpgillwhvssqslsfdssnpeyfdgywgysva
vgefdgdlntteyvvgaptwswtlgaveildsyyqrlhrlraeqmasyfghsvavtdvng
dgrhdllvgaplymesradrklaevgrvylflqprgphalgapsllltgtqlygrfgsai
aplgdldrdgyndiavaapyggpsgrgqvlvflgqseglrsrpsqvldspfptgsafgfs
lrgavdiddngypdlivgayganqvavyraqp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1ty6B (B:)
gpnicttrgvsscqqclavspmcawcsdealplgsprcdlkenllkdncapesiefpvse
arvledrplsdkgsgdssqvtqvspqrialrlrpddsknfsiqvrqvedypvdiyylmdl
sysmkddlwsiqnlgtklatqmrkltsnlrigfgafvdkpvspymyisppealenpcydm
kttclpmfgykhvltltdqvtrfneevkkqsvsrnrdapeggfdaimqatvcdekigwrn
dashllvfttdakthialdgrlagivqpndgqchvgsdnhysasttmdypslglmtekls
qkninlifavtenvvnlyqnyselipgttvgvlsmdssnvlqlivdaygkirskvelevr
dlpeelslsfnatclnnevipglkscmglkigdtvsfsieakvrgcpqekeksftikpvg
fkdslivqvtfdcdcacqaq

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1ty6H (H:)
evqlqqsgaelvkpgasvklsctasgfnikdtyvhwvkqrpeqglewigridpangytky
dpkfqgkatitadtssntaylqlssltsedtavyycvrplydyyamdywgqgtsvtvssa
kttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkiepr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1ty6L (L:)
dilmtqspssmsvslgdtvsitchasqgissnigwlqqkpgksfmgliyygtnlvdgvps
rfsgsgsgadysltissldsedfadyycvqyaqlpytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

  • Chain 'X':
    No sequence available.