PDB entry 1ty6
View 1ty6 on RCSB PDB site
Description: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Class: cell adhesion/immune system
Keywords: crystal structure; platelet integrin alphaIIBbeta3; fibrinogen binding; allostery; therapeutic antagonism, CELL ADHESION/IMMUNE SYSTEM COMPLEX
Deposited on
2004-07-07, released
2004-10-12
The last revision prior to the SCOPe 2.08 freeze date was dated
2008-09-02, with a file datestamp of
2008-08-29.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.2
AEROSPACI score: 0.26
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: integrin alpha-IIb
Species: Homo sapiens [TaxId:9606]
Gene: ITGAB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1ty6a_ - Chain 'B':
Compound: integrin beta-3
Species: Homo sapiens [TaxId:9606]
Gene: ITGAB
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d1ty6b4, d1ty6b5, d1ty6b6 - Chain 'H':
Compound: monoclonal antibody 10e5 heavy chain
Species: Mus musculus [TaxId:10090]
Domains in SCOPe 2.08: d1ty6h_ - Chain 'L':
Compound: monoclonal antibody 10e5 light chain
Species: Mus musculus [TaxId:10090]
Domains in SCOPe 2.08: d1ty6l3, d1ty6l4 - Chain 'X':
Compound: eptifibatide
- Heterogens: NAG, NDG, MG, CA, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1ty6A (A:)
lnldpvqltfyagpngsqfgfsldfhkdshgrvaivvgaprtlgpsqeetggvflcpwra
eggqcpsllfdlrdetrnvgsqtlqtfkarqglgasvvswsdvivacapwqhwnvlekte
eaektpvgscflaqpesgrraeyspcrgntlsriyvendfswdkryceagfssvvtqage
lvlgapggyyflgllaqapvadifssyrpgillwhvssqslsfdssnpeyfdgywgysva
vgefdgdlntteyvvgaptwswtlgaveildsyyqrlhrlraeqmasyfghsvavtdvng
dgrhdllvgaplymesradrklaevgrvylflqprgphalgapsllltgtqlygrfgsai
aplgdldrdgyndiavaapyggpsgrgqvlvflgqseglrsrpsqvldspfptgsafgfs
lrgavdiddngypdlivgayganqvavyraqp
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1ty6B (B:)
gpnicttrgvsscqqclavspmcawcsdealplgsprcdlkenllkdncapesiefpvse
arvledrplsdkgsgdssqvtqvspqrialrlrpddsknfsiqvrqvedypvdiyylmdl
sysmkddlwsiqnlgtklatqmrkltsnlrigfgafvdkpvspymyisppealenpcydm
kttclpmfgykhvltltdqvtrfneevkkqsvsrnrdapeggfdaimqatvcdekigwrn
dashllvfttdakthialdgrlagivqpndgqchvgsdnhysasttmdypslglmtekls
qkninlifavtenvvnlyqnyselipgttvgvlsmdssnvlqlivdaygkirskvelevr
dlpeelslsfnatclnnevipglkscmglkigdtvsfsieakvrgcpqekeksftikpvg
fkdslivqvtfdcdcacqaq
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>1ty6H (H:)
evqlqqsgaelvkpgasvklsctasgfnikdtyvhwvkqrpeqglewigridpangytky
dpkfqgkatitadtssntaylqlssltsedtavyycvrplydyyamdywgqgtsvtvssa
kttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkiepr
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>1ty6L (L:)
dilmtqspssmsvslgdtvsitchasqgissnigwlqqkpgksfmgliyygtnlvdgvps
rfsgsgsgadysltissldsedfadyycvqyaqlpytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec
- Chain 'X':
No sequence available.