PDB entry 1txv
View 1txv on RCSB PDB site
Description: Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
Class: cell adhesion/immune system
Keywords: crystal structure; platelet integrin alphaIIBbeta3; fibrinogen binding; allostery;
therapeutic antagonism
Deposited on
2004-07-06, released
2004-10-12
The last revision prior to the SCOP 1.73 freeze date was dated
2004-11-09, with a file datestamp of
2007-06-04.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.201
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: integrin alpha-IIb
Species: HOMO SAPIENS
Gene: ITGAB
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d1txva_ - Chain 'B':
Compound: integrin beta-3
Species: HOMO SAPIENS
Gene: ITGAB
Database cross-references and differences (RAF-indexed):
Domains in SCOP 1.73: d1txvb1, d1txvb2, d1txvb3 - Chain 'H':
Compound: monoclonal antibody 10e5 heavy chain
Species: Mus musculus
Domains in SCOP 1.73: d1txvh1, d1txvh2 - Chain 'L':
Compound: monoclonal antibody 10e5 light chain
Species: Mus musculus
Domains in SCOP 1.73: d1txvl1, d1txvl2 - Heterogens: NAG, NDG, CAC, MG, CA, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>1txvA (A:)
lnldpvqltfyagpngsqfgfsldfhkdshgrvaivvgaprtlgpsqeetggvflcpwra
eggqcpsllfdlrdetrnvgsqtlqtfkarqglgasvvswsdvivacapwqhwnvlekte
eaektpvgscflaqpesgrraeyspcrgntlsriyvendfswdkryceagfssvvtqage
lvlgapggyyflgllaqapvadifssyrpgillwhvssqslsfdssnpeyfdgywgysva
vgefdgdlntteyvvgaptwswtlgaveildsyyqrlhrlraeqmasyfghsvavtdvng
dgrhdllvgaplymesradrklaevgrvylflqprgphalgapsllltgtqlygrfgsai
aplgdldrdgyndiavaapyggpsgrgqvlvflgqseglrsrpsqvldspfptgsafgfs
lrgavdiddngypdlivgayganqvavyraqp
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>1txvB (B:)
gpnicttrgvsscqqclavspmcawcsdealplgsprcdlkenllkdncapesiefpvse
arvledrplsdkgsgdssqvtqvspqrialrlrpddsknfsiqvrqvedypvdiyylmdl
sysmkddlwsiqnlgtklatqmrkltsnlrigfgafvdkpvspymyisppealenpcydm
kttclpmfgykhvltltdqvtrfneevkkqsvsrnrdapeggfdaimqatvcdekigwrn
dashllvfttdakthialdgrlagivqpndgqchvgsdnhysasttmdypslglmtekls
qkninlifavtenvvnlyqnyselipgttvgvlsmdssnvlqlivdaygkirskvelevr
dlpeelslsfnatclnnevipglkscmglkigdtvsfsieakvrgcpqekeksftikpvg
fkdslivqvtfdcdcacqaq
- Chain 'H':
Sequence; same for both SEQRES and ATOM records: (download)
>1txvH (H:)
evqlqqsgaelvkpgasvklsctasgfnikdtyvhwvkqrpeqglewigridpangytky
dpkfqgkatitadtssntaylqlssltsedtavyycvrplydyyamdywgqgtsvtvssa
kttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdl
ytlsssvtvtsstwpsqsitcnvahpasstkvdkkiepr
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>1txvL (L:)
dilmtqspssmsvslgdtvsitchasqgissnigwlqqkpgksfmgliyygtnlvdgvps
rfsgsgsgadysltissldsedfadyycvqyaqlpytfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec