PDB entry 1tw7

View 1tw7 on RCSB PDB site
Description: Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Class: hydrolase
Keywords: HIV protease, AIDS, polyprotein, hydrolase, aspartyl protease, multi-drug resistance
Deposited on 2004-06-30, released 2005-07-19
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.142
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: HIV-1
  Database cross-references and differences (RAF-indexed):
  • GB AAP15109 (0-98)
    • engineered (9)
    • engineered (24)
    • engineered (35)
    • engineered (45)
    • engineered (53)
    • engineered (61-62)
    • engineered (70)
    • engineered (81)
    • engineered (83)
    • engineered (89)
  Domains in SCOPe 2.06: d1tw7a_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus 1 [TaxId:11676]
  Gene: HIV-1
  Database cross-references and differences (RAF-indexed):
  • GB AAP15109 (0-98)
    • engineered (9)
    • engineered (24)
    • engineered (35)
    • engineered (45)
    • engineered (53)
    • engineered (61-62)
    • engineered (70)
    • engineered (81)
    • engineered (83)
    • engineered (89)
  Domains in SCOPe 2.06: d1tw7b_
• Heterogens: NA, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1tw7A (A:)
  pqitlwqrpivtikiggqlkeallntgaddtvleevnlpgrwkpkliggiggfvkvrqyd
  qvpieicghkvigtvlvgptpanvigrnlmtqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >1tw7B (B:)
  pqitlwqrpivtikiggqlkeallntgaddtvleevnlpgrwkpkliggiggfvkvrqyd
  qvpieicghkvigtvlvgptpanvigrnlmtqigctlnf