PDB entry 1tno

View 1tno on RCSB PDB site
Description: Rat Protein Geranylgeranyltransferase Type-I Complexed with a GGPP analog and a KKKSKTKCVIM Peptide Derived from K-Ras4B
Class: Transferase
Keywords: GGTase-I, geranylgeranyltransferase type-I, geranylgeranyl transferase, prenyltransferase, CaaX, Ras, K-Ras, Lipid modification, prenylation, substrate selectivity
Deposited on 2004-06-11, released 2004-11-02
The last revision prior to the SCOP 1.75 freeze date was dated 2004-11-02, with a file datestamp of 2007-06-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.194
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoa_
  • Chain 'B':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnob_
  • Chain 'C':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoc_
  • Chain 'D':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnod_
  • Chain 'E':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoe_
  • Chain 'F':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnof_
  • Chain 'G':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnog_
  • Chain 'H':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoh_
  • Chain 'I':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoi_
  • Chain 'J':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnoj_
  • Chain 'K':
    Compound: geranylgeranyltransferase type I alpha subunit
    Species: Rattus norvegicus
    Gene: Fnta
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnok_
  • Chain 'L':
    Compound: Geranylgeranyl transferase type I beta subunit
    Species: Rattus norvegicus
    Gene: PGGT1B
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d1tnol_
  • Chain 'M':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Chain 'N':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Chain 'O':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Chain 'P':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Chain 'Q':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Chain 'R':
    Compound: c-K-ras2 protein isoform b
    Species: synthetic, synthetic
  • Heterogens: ZN, CL, MES, MGM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tnoA (A:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoA (A:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >1tnoB (B:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoB (B:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >1tnoC (C:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoC (C:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >1tnoD (D:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoD (D:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >1tnoE (E:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoE (E:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >1tnoF (F:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoF (F:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >1tnoG (G:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoG (G:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >1tnoH (H:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoH (H:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >1tnoI (I:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoI (I:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >1tnoJ (J:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoJ (J:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >1tnoK (K:)
maategvgesapggepgqpeqpppppppppaqqpqeeemaaeageaaaspmddgflslds
ptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderserafklt
rdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrvlvewlk
dpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnnsvwnqr
hfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypnllnqll
dlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirkeywryig
rslqskhsresdipasv

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoK (K:)
flsldsptyvlyrdraewadidpvpqndgpspvvqiiysekfrdvydyfravlqrderse
rafkltrdaielnaanytvwhfrrvllrslqkdlqeemnyiiaiieeqpknyqvwhhrrv
lvewlkdpsqelefiadilnqdaknyhawqhrqwviqefrlwdnelqyvdqllkedvrnn
svwnqrhfvisnttgysdravlerevqytlemiklvphnesawnylkgilqdrglsrypn
llnqlldlqpshsspyliaflvdiyedmlenqcdnkedilnkalelceilakekdtirke
ywryigrslqskhs

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >1tnoL (L:)
maateddrlagsgegerldflrdrhvrffqrclqvlperyssletsrltiaffalsgldm
ldsldvvnkddiiewiyslqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsg
hiamtytglscliilgddlsrvdkeaclaglralqledgsfcavpegsendmrfvycasc
icymlnnwsgmdmkkaisyirrsmsydnglaqgagleshggstfcgiaslclmgkleevf
sekelnrikrwcimrqqngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyils
tqdrlvggfakwpdshpdalhayfgicglslmeesgickvhpalnvstrtserlrdlhqs
wktkdskqcsdnvhiss

    Sequence, based on observed residues (ATOM records): (download) 
    >1tnoL (L:)
ldflrdrhvrffqrclqvlperyssletsrltiaffalsgldmldsldvvnkddiiewiy
slqvlptedrsnldrcgfrgssylgipfnpsknpgtahpydsghiamtytglscliilgd
dlsrvdkeaclaglralqledgsfcavpegsendmrfvycascicymlnnwsgmdmkkai
syirrsmsydnglaqgagleshggstfcgiaslclmgkleevfsekelnrikrwcimrqq
ngyhgrpnkpvdtcysfwvgatlkllkifqytnfeknrnyilstqdrlvggfakwpdshp
dalhayfgicglslmeesgickvhpalnvstrtserlrdlhqswkt

  • Chain 'M':
    No sequence available.

  • Chain 'N':
    No sequence available.

  • Chain 'O':
    No sequence available.

  • Chain 'P':
    No sequence available.

  • Chain 'Q':
    No sequence available.

  • Chain 'R':
    No sequence available.