PDB entry 1tfx

View 1tfx on RCSB PDB site
Description: complex of the second kunitz domain of tissue factor pathway inhibitor with porcine trypsin
Class: complex (serine protease/inhibitor)
Keywords: complex (serine protease/inhibitor), hydrolase, inhibitor, blood coagulation
Deposited on 1997-01-21, released 1998-01-21
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.162
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Trypsin
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1tfxa_
  • Chain 'B':
    Compound: Trypsin
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1tfxb_
  • Chain 'C':
    Compound: tissue factor pathway inhibitor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1tfxc_
  • Chain 'D':
    Compound: tissue factor pathway inhibitor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d1tfxd_
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tfxA (A:)
ivggytcaansipyqvslnsgshfcggslinsqwvvsaahcyksriqvrlgehnidvleg
neqfinaakiithpnfngntldndimliklsspatlnsrvatvslprscaaagteclisg
wgntkssgssypsllqclkapvlsdssckssypgqitgnmicvgfleggkdscqgdsggp
vvcngqlqgivswgygcaqknkpgvytkvcnyvnwiqqtiaan

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tfxB (B:)
ivggytcaansipyqvslnsgshfcggslinsqwvvsaahcyksriqvrlgehnidvleg
neqfinaakiithpnfngntldndimliklsspatlnsrvatvslprscaaagteclisg
wgntkssgssypsllqclkapvlsdssckssypgqitgnmicvgfleggkdscqgdsggp
vvcngqlqgivswgygcaqknkpgvytkvcnyvnwiqqtiaan

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tfxC (C:)
kpdfcfleedpgicrgyitryfynnqtkqcerfkyggclgnmnnfetleecknicedg

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >1tfxD (D:)
kpdfcfleedpgicrgyitryfynnqtkqcerfkyggclgnmnnfetleecknicedg