PDB entry 1tbf

View 1tbf on RCSB PDB site
Description: Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
Class: hydrolase
Keywords: PDE5A, hydrolase
Deposited on 2004-05-20, released 2004-08-03
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: 0.159
AEROSPACI score: 0.78 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE5A, PDE5
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76074 (21-346)
      • engineered (145)
      • engineered (148)
      • engineered (150-158)
      • engineered (161-163)
      • engineered (165-166)
      • engineered (168-169)
    Domains in SCOPe 2.05: d1tbfa_
  • Heterogens: ZN, MG, VIA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >1tbfA (A:)
mgsshhhhhhssglvprgshmeeetrelqslaaavvpsaqtlkitdfsfsdfelsdleta
lctirmftdlnlvqnfqmkhevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkag
kiqnkltdleilalliaalshdldhpgvsnqflintnselalmyndesvlehhhfdqclm
ilnspgnqilsglsieeykttlkiikqailatdlalyikrrgeffelirknqfnledphq
kelflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkelnieptdlmnrekkn
kipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalae

    Sequence, based on observed residues (ATOM records): (download) 
    >1tbfA (A:)
eeetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhpgvsnqflintnselalmyndesvlehhhfdqclmilnspgnqilsglsieeyktt
lkiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpw
piqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyeal
thvsedcfplldgcrknrqkwqalae